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IK1 inhibitor PA-6

Cat. No. M14255

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IK1 inhibitor PA-6 Structure
Synonym:

PA-6

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Quality Control & Documentation
Biological Activity

IK1 inhibitor PA-6 (PA-6), a pentamidine analogue, is a selective and potent IK1 (KIR2.x ion-channel-carried inward rectifier current) inhibitor, with IC50 values of 12-15 nM for human and mouse KIR2.x currents. IK1 inhibitor PA-6 (PA-6) elevates KIR2.1 protein expression and induces intracellular KIR2.1 accumulation. IK1 inhibitor PA-6 (PA-6) has the potential to treat atrial fibrillation and arrhythmia.

Chemical Information
Molecular Weight 492.61
CAS Number 500715-03-7
Solubility (25°C) DMSO 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Yuan Ji, et al. PA-6 inhibits inward rectifier currents carried by V93I and D172N gain-of-function K IR 2.1 channels, but increases channel protein expression

[2] Yuan Ji, et al. The inward rectifier current inhibitor PA-6 terminates atrial fibrillation and does not cause ventricular arrhythmias in goat and dog models

[3] Gregory S Hoeker, et al. Electrophysiologic effects of the IK1 inhibitor PA-6 are modulated by extracellular potassium in isolated guinea pig hearts

[4] Mark A Skarsfeldt, et al. Pharmacological inhibition of IK1 by PA-6 in isolated rat hearts affects ventricular repolarization and refractoriness

[5] Hiroki Takanari, et al. Efficient and specific cardiac IK₁ inhibition by a new pentamidine analogue

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Keywords: IK1 inhibitor PA-6, PA-6 supplier, Potassium Channel, inhibitors, activators

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