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Potassium channel blocker. Antimalarial, anticholinergic, antihypertensive, and hypoglycemic agent; alkaloid originally isolated from the Cinchona family of South American trees. Inhibits mitochondrial ATP-regulated potassium channel. Used to study the metabolism of biocrystalized heme, hemozoin, in malarial parasites and to study the toxicity of heme (FP)-complexes.
| Molecular Weight | 391.47 |
| Formula | C20H24N2O2 · 0.5H2O4S · H2O |
| CAS Number | 207671-44-1 |
| Solubility (25°C) | Water: slightly soluble 1.2 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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