| Cat.No. | Name | Information |
|---|---|---|
| M4973 | BAPTA-AM | BAPTA-AM is a selective, membrane-permeable calcium chelator. BAPTA-AM inhibits hERG channels, hKv1.3 and hKv1.5 channels in HEK 293 cells with IC50s of 1.3 μM, 1.45 μM and 1.23 μM, respectively. |
| M2181 | ML133 hydrochloride | ML133 hydrochloride is a selective inhibitor of the Kir2 family of inward rectifier (IRK, KCNJ) potassium channels. |
| M3456 | Chlorpromazine hydrochloride | Chlorpromazine hydrochloride is an antagonist of D2, 5HT2A, potassium and sodium channels. The Ki of Chlorpromazine Hydrochloride to D2 and 5HT2A were 363 nM and 8.3 nM, respectively. Chlorpromazine also excites the 20S proteasome. *The compound is unstable in solutions, freshly prepared is recommended |
| M7029 | Nigericin sodium salt | Nigericin (NSC 292567) sodium salt is a selective K+ ionophore, Nigericin sodium salt is also an NLRP3 activator which can activate NLRP3 inflammasome to induce pro-inflammatory and immunostimulatory processes. |
| M20428 | Retigabine 2HCl | Retigabine is a novel anticonvulsant with activity in a broad range of seizure models. The mechanism of action involves opening of neuronal K(V)7.2-7.5 (formerly KCNQ2-5) voltage-activated K(+) channels. |
| M9780 | Nigericin | Nigericin is an antibiotic derived from Streptomyces hygroscopicus, it acts as an H+, K+, Pb2+ ionophore. |
| M52730 | Maurotoxin | Maurotoxin is a 34-residue and four disulde-bridged toxin that can be isolated from the chactoid scorpion (Scorpio maurus). |
| M52729 | Vm24-toxin | Vm24-toxin is a toxin peptide that can be isolated from the Mexican scorpion Vaejovis mexicanus smithy. |
| M52728 | ShK toxin | ShK toxin blocks voltage-dependent potassium channel (Kv1.3 channel). |
| M52727 | PE 22-28 | PE 22-28 is a TREK-1 inhibitor with IC50 value of 0.12 nM. |
| M52726 | Spinoxin | Spinoxin isolated from the venom of scorpion Heterometrus spinifer, is a 34-residue peptide neurotoxin cross-linked by four disulfide bridges. |
| M52725 | HsTX1 | HsTX1, from the scorpion Heterometrus spinnifer, is a 34-residue, C-terminally amidated peptide cross-linked by four disulfide bridges. |
| M49431 | Dendrotoxin K TFA | Dendrotoxin K TFA is a Kv1.1 channel blocker that controls the release of glutamate from presynaptic spike waves into CA3 neurons in a time-dependent manner. |
| M43879 | Isopropyl unoprostone | UF-021, an analog of a prostaglandin metabolite and activator of large conductance calcium-activated potassium channels (BK channels), lowers intraocular pressure (IOP) by increasing aqueous humor outflow, and may be used in studies related to glaucoma. |
| M42246 | PD-307243 | PD-307243 is a hERG channel activator. |
| M42245 | Kv3 modulator 5 | Kv3 modulator 5 is a Kv3 channel modulator. |
| M42244 | Clobutinol hydrochloride | Clobutinol hydrochloride is a compound that has anti-tussive effects. |
| M42243 | ZM226600 | ZM226600 is an ATP-sensitive potassium channel opener (EC50: 500 nM). |
| M42242 | Tamapin TFA | Tamapin TFA is a venom peptide, targeting to small conductance Ca(2+)-activated K(+) (SK) channels. |
| M42241 | AmmTX3 | AmmTX3 is a peptide toxin that can be isolated from the venom of the scorpion Androctonus mauretanicus. |
| M42240 | BDS-I | BDS-I known as blood depressing substance, is a marine toxin which can be extracted from Anemonia sulcata. |
| M42239 | VU590 dihydrochloride | VU590 dihydrochloride is a potent and moderately selective ROMK (Kir1.1) inhibitor, with an IC50 of 290 nM. |
| M42238 | KV1.3-IN-1 | KV1.3-IN-1 is a KV1.3 channel inhibitor (IC50: 230 nM and 26.12 nM in Ltk cells and PHA-activated T-lymphocytes respectively). |
| M42237 | SKA-111 | SKA-111 is a selective activator of potassium phannel KCa 3.1 , evokes KCa 3.1 membrane hyperpolarization in porcine endothelial cell. |
| M42236 | BmP02 | BmP02 is a selective Kv1.3 channel blocker and a highly-selective Kv4.2 modulator, which can be isolated from Chinese scorpion (Buthus martensi Karsch) venom. |
| M42235 | Budiodarone tartrate | Budiodarone (ATI-2042) tartrate is a chemical analogue of Amiodarone with balanced, multiple cardiac ion channel (potassium, sodium and calcium channels) inhibiting activity. |
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