BAPTA-AM exerts an open channel blocking effect on hERG, hKv1.3 and hKv1.5 channels with IC50 of 1.3, 1.45 and 1.23 μM in HEK 293 cells. BAPTA-AM, as an intracellular calcium chelator, induces delayed necrosis by lipoxygenase-mediated free radicals in mouse cortical cultures.
Ecotoxicol Environ Saf. 2021 Sep 1;220:112341.
Cadmium induces apoptosis of human granulosa cell line KGN via mitochondrial dysfunction-mediated pathways
BAPTA-AM purchased from AbMole
Ecotoxicol Environ Saf. 2021 Jan 15;208:111429.
Environ Pollut. 2021 Feb 1;270:116051.
|Source||ECOTOX ENVIRON SAFE 2021 Jan. Figure 5. BAPTA-AM (Abmole Bioscience Inc, Houston, TX, USA)|
|Cell Lines||KGN cells|
|Results||We further pretreated KGN cells with BAPTA-AM (a calcium chelator) and found that BPA-induced phosphorylation of JNK and ASK1 proteins and apoptosis of KGN cells was significantly inhibited|
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
|Solubility||DMSO 20 mg/mL|
The membrane permeable calcium chelator BAPTA-AM directly blocks human ether a-go-go-related gene potassium channels stably expressed in HEK 293 cells.
Tang Q,et.al. Biochem Pharmacol 2007 Dec 3;1596-607. PMID: 17826747.
17 alpha-Estradiol is a 5α-reductase inhibitor, and it inhibits testosterone metabolism catalyzed by 5 alpha-reductase.
Rebaudioside M is a natural non-calorie sweetener isolated from Stevia rebaudiana Bertoni, it is a glycoside of the ent-kaurene diterpenoid aglycone.
β-Aminopropionitrile is a specific and irreversible lysyl oxidase (LOX) inhibitor.
1-Phenyl-2-thiourea is a useful biochemical for proteomics research.
Tentoxin is a cyclic tetrapeptide isolated from Alternaria tenuis, acts as a herbicide, causes seedling chlorosis, inhibits cyclic photophosphorylation and functions as an energy transfer inhibitor.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.