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Cat. No. M4973
BAPTA-AM Structure
Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
5mg USD 70  USD70 In stock
10mg USD 100  USD100 In stock
50mg USD 350  USD350 In stock
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Quality Control & Documentation
Biological Activity

BAPTA-AM exerts an open channel blocking effect on hERG, hKv1.3 and hKv1.5 channels with IC50 of 1.3, 1.45 and 1.23 μM in HEK 293 cells. BAPTA-AM, as an intracellular calcium chelator, induces delayed necrosis by lipoxygenase-mediated free radicals in mouse cortical cultures. BAPTA-AM prevents free radical-mediated toxicity promote apoptosis in non-neuronal cells and produce a beneficial effect in neuronal cells by protecting neurons from ischemic damage. In addition, it has been suggested that BAPTA-AM induces a late, but not early, increase of intracellular calcium in I-IL-60 neoplastic cells. Mixed cortical cell cultures (DIV 13-16) exposed to 10 μM BAPTA-AM for 24- or 48-hr show moderate (45-70%) neuronal injury as evaluated by increased LDH release into the bathing medium after 24-48-hr.

Product Citations
Customer Product Validations & Biological Datas
Source ECOTOX ENVIRON SAFE 2021 Jan. Figure 5. BAPTA-AM (Abmole Bioscience Inc, Houston, TX, USA)
Method cell culture
Cell Lines KGN cells
Concentrations 10 μM
Incubation Time 1h
Results We further pretreated KGN cells with BAPTA-AM (a calcium chelator) and found that BPA-induced phosphorylation of JNK and ASK1 proteins and apoptosis of KGN cells was significantly inhibited
Chemical Information
Molecular Weight 764.68
Formula C34H40N2O18
CAS Number 126150-97-8
Solubility (25°C) DMSO 40 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Tang Q, Biochem Pharmacol The membrane permeable calcium chelator BAPTA-AM directly blocks human ether a-go-go-related gene potassium channels stably expressed in HEK 293 cells.

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Keywords: BAPTA-AM supplier, Potassium Channel, inhibitors, activators

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