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Cat. No. M4973
BAPTA-AM Structure
Size Price Availability Quantity
10mg USD 76.5  USD85 In stock
50mg USD 265.5  USD295 In stock
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Quality Control
Biological Activity

BAPTA-AM exerts an open channel blocking effect on hERG, hKv1.3 and hKv1.5 channels with IC50 of 1.3, 1.45 and 1.23 μM in HEK 293 cells. BAPTA-AM, as an intracellular calcium chelator, induces delayed necrosis by lipoxygenase-mediated free radicals in mouse cortical cultures.

Product Citations
Customer Product Validations & Biological Datas
Source ECOTOX ENVIRON SAFE 2021 Jan. Figure 5. BAPTA-AM (Abmole Bioscience Inc, Houston, TX, USA)
Method cell culture
Cell Lines KGN cells
Concentrations 10 μM
Incubation Time 1h
Results We further pretreated KGN cells with BAPTA-AM (a calcium chelator) and found that BPA-induced phosphorylation of JNK and ASK1 proteins and apoptosis of KGN cells was significantly inhibited
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 764.68
Formula C34H40N2O18
CAS Number 126150-97-8
Purity 99.09%
Solubility DMSO 20 mg/mL
Storage at -20°C

The membrane permeable calcium chelator BAPTA-AM directly blocks human ether a-go-go-related gene potassium channels stably expressed in HEK 293 cells.
Tang Q, Biochem Pharmacol 2007 Dec 3;1596-607. PMID: 17826747.

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Keywords: BAPTA-AM supplier, inhibitors

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