Free shipping on all orders over $ 500

BAPTA-AM

Cat. No. M4973
BAPTA-AM Structure
Size Price Availability Quantity
10mg USD 76.5  USD85 In stock
50mg USD 265.5  USD295 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
Biological Activity

BAPTA-AM exerts an open channel blocking effect on hERG, hKv1.3 and hKv1.5 channels with IC50 of 1.3, 1.45 and 1.23 μM in HEK 293 cells. BAPTA-AM, as an intracellular calcium chelator, induces delayed necrosis by lipoxygenase-mediated free radicals in mouse cortical cultures.

Product Citations
Customer Product Validations & Biological Datas
Source ECOTOX ENVIRON SAFE 2021 Jan. Figure 5. BAPTA-AM (Abmole Bioscience Inc, Houston, TX, USA)
Method cell culture
Cell Lines KGN cells
Concentrations 10 μM
Incubation Time 1h
Results We further pretreated KGN cells with BAPTA-AM (a calcium chelator) and found that BPA-induced phosphorylation of JNK and ASK1 proteins and apoptosis of KGN cells was significantly inhibited
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 764.68
Formula C34H40N2O18
CAS Number 126150-97-8
Purity 99.09%
Solubility DMSO 20 mg/mL
Storage at -20°C
References

The membrane permeable calcium chelator BAPTA-AM directly blocks human ether a-go-go-related gene potassium channels stably expressed in HEK 293 cells.
Tang Q,et.al. Biochem Pharmacol 2007 Dec 3;1596-607. PMID: 17826747.

Related Products
17α-Estradiol

17 alpha-Estradiol is a 5α-reductase inhibitor, and it inhibits testosterone metabolism catalyzed by 5 alpha-reductase.

Rebaudioside M

Rebaudioside M is a natural non-calorie sweetener isolated from Stevia rebaudiana Bertoni, it is a glycoside of the ent-kaurene diterpenoid aglycone.

β-Aminopropionitrile (Liquid)

β-Aminopropionitrile is a specific and irreversible lysyl oxidase (LOX) inhibitor.

1-Phenyl-2-thiourea

1-Phenyl-2-thiourea is a useful biochemical for proteomics research.

Tentoxin

Tentoxin is a cyclic tetrapeptide isolated from Alternaria tenuis, acts as a herbicide, causes seedling chlorosis, inhibits cyclic photophosphorylation and functions as an energy transfer inhibitor.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: BAPTA-AM supplier, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.