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Indapamide

Cat. No. M3464
Indapamide Structure
Synonym:

Noranat; Veroxil; Tertensif

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
100mg USD 30  USD30 In stock
500mg USD 48  USD48 In stock
1g USD 60  USD60 In stock
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Quality Control & Documentation
Biological Activity

Indapamide is a non-thiazide sulphonamide diuretic compound, generally used in the treatment of hypertension, as well as decompensated cardiac failure. Indapamide helps prevent your body from absorbing too much salt, which can cause fluid retention. Indapamide treats fluid retention (edema) in people with congestive heart failure.

Customer Product Validations & Biological Datas
Source J Pharmacol Exp Ther (2008). Figure 5. Indapamide
Method BM-MNC Differentiation into EPCs.
Cell Lines normotensive Wistar Kyoto (WKY) rats
Concentrations 10 μM
Incubation Time 7 d
Results It is noteworthy that treatment with perindopril, indapamide, or both increased the number of cells double positive for both AcDil-LDL and BS-1 lectin by 1.7-, 1.4-, and 2.0-fold, (p  0.01), respectively, in ischemic SHRs in reference to untreated ischemic SHRs
Source J Pharmacol Exp Ther (2008). Figure 3. Indapamide
Method Western Blot
Cell Lines normotensive Wistar Kyoto (WKY) rats
Concentrations 10 μM
Incubation Time 7 d
Results It is interesting to note that coadministration of perindopril and indapamide markedly increased VEGF protein expression in ischemic SHRs in reference to untreated ischemic SHRs
Protocol (for reference only)
Cell Experiment
Cell lines Rat A10 vascular smooth muscle cells
Preparation method The cultures were then incubated in DMEM with 10% foetal calf serum, containing vehicle alone or various concentrations of indapamide Ž10y6 ,10y5, 5=10y5 and 5=10y4 . for 16 h, then for 2 h in the same medium containing BrdU Ž10y5 M..
Concentrations 1, 10, 50, 500 μM
Incubation time 16 h
Animal Experiment
Animal models
Formulation
Dosages
Administration
Chemical Information
Molecular Weight 365.83
Formula C16H16ClN3O3S
CAS Number 26807-65-8
Solubility (25°C) DMSO 63 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Ganado P, et al. Eur J Pharmacol. Growth inhibitory activity of indapamide on vascular smooth muscle cells.

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Keywords: Indapamide, Noranat; Veroxil; Tertensif supplier, Potassium Channel, inhibitors, activators


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