Indapamide is a non-thiazide sulphonamide diuretic compound, generally used in the treatment of hypertension, as well as decompensated cardiac failure. Indapamide helps prevent your body from absorbing too much salt, which can cause fluid retention. Indapamide treats fluid retention (edema) in people with congestive heart failure.
Cell Experiment | |
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Cell lines | Rat A10 vascular smooth muscle cells |
Preparation method | The cultures were then incubated in DMEM with 10% foetal calf serum, containing vehicle alone or various concentrations of indapamide Ž10y6 ,10y5, 5=10y5 and 5=10y4 . for 16 h, then for 2 h in the same medium containing BrdU Ž10y5 M.. |
Concentrations | 1, 10, 50, 500 μM |
Incubation time | 16 h |
Animal Experiment | |
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Animal models | |
Formulation | |
Dosages | |
Administration |
Molecular Weight | 365.83 |
Formula | C16H16ClN3O3S |
CAS Number | 26807-65-8 |
Solubility (25°C) | DMSO 63 mg/mL |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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