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Talatisamine

Cat. No. M4031
Talatisamine Structure
Size Price Availability Quantity
20mg USD 200  USD200 In stock
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Quality Control & Documentation
Biological Activity

Talatisamine isa kind of aconite alkaloid, which isa specific K+ channel blocker. Talatisamine attenuated the neurotoxicity of beta-amyloid oligomers to cultured cortical neurons.

Chemical Information
Molecular Weight 421.574
Formula C24H39NO5
CAS Number 20501-56-8
Solubility (25°C) 10 mM in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Alice R Wong, et al. Total Syntheses of the C 19 Diterpenoid Alkaloids (-)-Talatisamine, (-)-Liljestrandisine, and (-)-Liljestrandinine by a Fragment Coupling Approach

[2] Merve Demirbağ Karaali, et al. Investigation of the potential anticancer effects of napelline and talatisamine dirterpenes on experimental brain tumor models

[3] Daiki Kamakura, et al. Total Synthesis of Talatisamine

[4] Mengchun Chen, et al. Quantitative determination of talatisamine and its pharmacokinetics and bioavailability in mouse plasma by UPLC-MS/MS

[5] Toshiki Tabuchi, et al. Construction of the Fused Pentacycle of Talatisamine via a Combination of Radical and Cationic Cyclizations

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