All AbMole products are for research use only, cannot be used for human consumption.
NS-1619 induced concentration-dependent activation of BKCa channels with a calculated EC50 of 32 microM. The NS-1619-induced activity was dependent on the presence of free Ca2+ at the intracellular surface, but was not associated with a change in channel voltage sensitivity. NS-1619 (50 microM) inhibited the noradrenaline-induced contraction. NS-1619 (10-100 microM) reduced the high K+-induced contractions in a noncompetitive manner. NS-1619 inhibits proliferation and induces apoptosis in A2780 ovarian cancer cells.
| Molecular Weight | 362.23 |
| Formula | C15H8F6N2O2 |
| CAS Number | 153587-01-0 |
| Form | Solid |
| Solubility (25°C) | DMSO 24 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Lee K,et.al. Eur J Pharmacol. NS 1619 activates BKCa channel activity in rat cortical neurones.
| Related Potassium Channel Products |
|---|
| VU0810464
VU0810464 is a potent and selective non-ureaG protein-gated inwardly-rectifying potassium channels (GIRK, Kir3) activator. VU0810464 displays nanomolar potency for neuronal (EC50=165 nM) and GIRK1/4 (EC50=720 nM) channels with improved brain penetration. |
| QO 58
QO 58 is a potent modulator of K(v)7 channels. |
| NS3623
NS3623 is an activator of human ether-a-go-go-related gene (hERG1/KV11.1) potassium channels. |
| ML67-33
ML67-33 is a selective activator of temperature- and mechano-sensitive K2P channels. |
| A-935142
A-935142 is a human ether-a-go-go-related gene (hERG, Kv 11.1) channel activator. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.
