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Amiodarone

Cat. No. M5409
Amiodarone  Structure
Size Price Availability Quantity
50mg USD 70  USD70 In stock
100mg USD 110  USD110 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Amiodarone HCl is a sodium/potassium-ATPase inhibitor and an autophagy activator, used to treat various types of cardiac dysrhythmias.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 681.77
Formula C25H29I2NO3.HCl
CAS Number 19774-82-4
Purity >98%
Solubility 23 mg/mL in DMSO
Storage at -20°C
References

[1] Rodrigues M, et al. J Pharm Pharm Sci. Herb-drug pharmacokinetic interaction between carica papaya extract and amiodarone in rats.

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Keywords: Amiodarone supplier, Potassium Channel, inhibitors

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