All AbMole products are for research use only, cannot be used for human consumption.
In vitro: PGE2 shows inhibition of IL 2 production in the mixture of irradiated and nonirradiated T lymphocytes. PGE2 (0.1-10 μM) dose-dependently inhibits the production of IL 2. PGE2 acts during the inductive phase of activation of suppressor cells. Preincubation of T lymphocytes with PGE2 induces cells that suppress IL 2 production and PHA proliferation.
In vivo: PGE2 (0.3 μg/k, i.p.) significantly reduces the number of peritoneab macrophages undergoing phagocytosis of the methacrybate microbeads in rats. PGE2 (0.1 mg/min, i.a.) increases renal blood flow. PGE2 produces a biphasic change in renal vascular resistance, vasodilatation starts at 0.01 mg/min and is maximal at about 3 mg/min, while at the highest dose used (20 mg/min) PGE2 induces renal vasoconstriction.
Cell Metab. 2024 Oct 18.
Adipocyte-derived glutathione promotes obesity-related breast cancer by regulating the SCARB2-ARF1-mTORC1 complex
Prostaglandin E2 purchased from AbMole
Cancer Lett. 2024 Oct 02;605:217284.
Exploring epigenetic dynamics unveils a super-enhancer-mediated NDRG1-β-catenin axis in modulating gemcitabine resistance in pancreatic cancer
Prostaglandin E2 purchased from AbMole
Toxicol Appl Pharmacol. 2024 Sep 24.
Human trophoblast organoids for improved prediction of placental ABC transporter-mediated drug transport
Prostaglandin E2 purchased from AbMole
Biochem Biophys Res Commun. 2023 Nov 12;681:55-61.
Antinociceptive effect of gelsenicine, principal toxic alkaloids of gelsemium, on prostaglandin E2-induced hyperalgesia in mice: Comparison with gelsemine and koumine
Prostaglandin E2 purchased from AbMole
Cell Death Dis. 2022 Apr 5;13(4):303.
KLF5 inhibition overcomes oxaliplatin resistance in patient-derived colorectal cancer organoids by restoring apoptotic response
Prostaglandin E2 purchased from AbMole
| Cell Experiment | |
|---|---|
| Cell lines | ovulatory follicles |
| Preparation method | All cells and tissues were obtained after ovarian stimulation before (0 h) and 12, 24, or 36 h after administration of an ovulatory dose of hCG. |
| Concentrations | |
| Incubation time | 12, 24, or 36 h |
| Animal Experiment | |
|---|---|
| Animal models | male dogs |
| Formulation | |
| Dosages | 0.1 mg/kg |
| Administration | oral |
| Molecular Weight | 352.47 |
| Formula | C20H32O5 |
| CAS Number | 363-24-6 |
| Solubility (25°C) | DMSO ≥ 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Prostaglandin Receptor Products |
|---|
| Prostaglandin D2
Prostaglandin D2 (PGD2) is one of the major PGs actively produced in the brain of various mammals. PGD2 plays a protective role by suppressing inflammation. |
| Tafluprost acid
Tafluprost acid (AFP-172) is a selective prostanoid FP receptor agonist. Tafluprost acid shows a high affinity for human prostanoid FP receptor with Ki and EC50 values of 0.4 nM and 0.53 nM, respectively. Tafluprost acid has 126 times weaker binding affinity for prostanoid EP3 receptor (IC50=67 nM) than for the prostanoid FP receptor. |
| TG8-260
TG8-260 is a second-generation EP2 antagonist developed to alleviate the pathology of central nervous system and peripheral diseases driven by inflammation. |
| Camonagrel
Camonagrel is a compound that has inhibitory effects on Prostaglandin E2. |
| BAY 73-1449
BAY 73-1449 is a selective antagonist of prostacyclin receptor (IP), with high potency (IC50 of less than 0.1 nM) in cAMP assays in Human HEL cells and rat DRG. |
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Products are for research use only. Not for human use. We do not sell to patients.
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