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Prostaglandin D2 (PGD2) is one of the major PGs actively produced in the brain of various mammals. PGD2 plays a protective role by suppressing inflammation. Prostaglandin D2 is a potent endogenous sleep promoting substances.
Prostaglandin D2 (5-50 pmol/min; infused into the lateral ventricle; for 6 hours between 20:00 and 2:00) induces sleep-wake profiles in A2AR KO mice.
| Molecular Weight | 352.47 |
| Formula | C20H32O5 |
| CAS Number | 41598-07-6 |
| Form | Solid |
| Solubility (25°C) | Ethanol 60 mg/mL |
| Storage | -20°C, sealed |
| Related Prostaglandin Receptor Products |
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Tafluprost acid (AFP-172) is a selective prostanoid FP receptor agonist. Tafluprost acid shows a high affinity for human prostanoid FP receptor with Ki and EC50 values of 0.4 nM and 0.53 nM, respectively. Tafluprost acid has 126 times weaker binding affinity for prostanoid EP3 receptor (IC50=67 nM) than for the prostanoid FP receptor. |
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| AZ12672857
AZ12672857 is an orally active inhibitor of EphB4 (IC50=1.3 nM) and Src kinases. |
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