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Glycine

Cat. No. M9566
Glycine Structure
Size Price Availability Quantity
10g USD 30  USD30 In stock
50g USD 33  USD33 In stock
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Quality Control
Biological Activity

Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate.

Product Citations
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 75.07
Formula C2H5NO2
CAS Number 56-40-6
Purity >99%
Solubility Water ≥ 5 mg/mL
Storage 2-8°C, dry, protect from light, sealed
References

[1] M Adeva-Andany, et al. Insulin resistance and glycine metabolism in humans

[2] Daniel C Javitt. Glycine modulators in schizophrenia

[3] J C Hall. Glycine

[4] A A Jackson. The glycine story

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Keywords: Glycine supplier, GluR, inhibitors

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