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Glycine

Cat. No. M9566
Glycine Structure
Size Price Availability Quantity
10g USD 30  USD30 In stock
50g USD 33  USD33 In stock
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Quality Control & Documentation
Biological Activity

Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate.

Product Citations
Chemical Information
Molecular Weight 75.07
Formula C2H5NO2
CAS Number 56-40-6
Solubility (25°C) Water ≥ 5 mg/mL
Storage 2-8°C, dry, protect from light, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] M Adeva-Andany, et al. Insulin resistance and glycine metabolism in humans

[2] Daniel C Javitt. Glycine modulators in schizophrenia

[3] J C Hall. Glycine

[4] A A Jackson. The glycine story

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Keywords: Glycine supplier, GluR, inhibitors, activators

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