Catalog

GluR Glutamate receptor

Inhibitors

Cat.No.	Name	Information
M10378	Cycloleucine	Cycloleucine is antagonist of NMDA receptor associated glycine receptor, with a Ki of 600 μM. Cycloleucine is a specific inhibitor of S-adenosyl-methionine mediated methylation.
M9869	L-Methionine sulfoximine	L-Methionine sulfoximine is a potent inhibitor of glutamine sythetase (GS) activity, used as a selection agent for plasmid integration in Chinese hamster ovary (CHO) and other mammalian cell lines.
M9646	Decoglurant	Decoglurant (also known as RO4995819) is a negative allosteric modulator of the mGlu2 and mGlu3 receptors.
M9566	Glycine	Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate.
M7707	CX546	CX546 is a selective positive AMPA glutamate receptor modulator.
M7581	(+)-MK 801 Maleate	(+)-MK 801 (Maleate) is a potent, selective and non-competitive NMDA receptor antagonist with Kd of 37.2 nM in rat brain membranes.
M7565	JNJ-42153605	JNJ-42153605 is a positive allosteric modulator of the metabotropic glutamate 2 (mGlu2) receptor with an EC50 of 17 nM.
M7111	PEPA	PEPA is a allosteric potentiator of AMPA receptor desensitization.
M6632	CPPG	CPPG is a potent group III mGlu antagonist.
M6321	1-BCP	1-BCP (Piperonylic acid piperidide) is a modulates AMPA-mediated responses.
M6071	Lu AF21934	Lu AF21934 is a selective and brain-penetrant mGlu4 receptor positive allosteric modulator with an IC50 of 500 nM for human mGlu4.
M5740	L-Glutamine	L-Glutamine (Gln) is one of the 20 amino acids encoded by the standard genetic code and also a major respiratory fuel and substrate for nucleic acid synthesis in mammalian intestinal cells.
M5446	Beclometasone dipropionate	Beclomethasone dipropionate is a potent glucocorticoid steroid used for the treatment of rhinitis and sinusitis.
M5157	Perampanel	Perampanel is a selective noncompetitive AMPA-type glutamate receptor antagonist.
M4950	Topiramate	Topiramate is an anticonvulsant that antagonizes GluR5 receptors and acts as a positive allosteric modulator of GABA receptor-mediated currents.
M3806	GLYX-13	GLYX-13 is a selective weak partial agonist of the glycine site of the NMDA receptor.
M3445	ADX-47273	ADX47273 is a potent and specific mGlu5 positive allosteric modulator(PAM) with EC50 of 0.17 μM, showing no activity at other mGlu subtypes.
M3253	(-)-Huperzine A	(-)-Huperzine A is a potent, highly specific and reversible inhibitor of acetylcholinesterase (AChE) with K_i of 7 nM, exhibiting 200-fold more selectivity for G4 AChE over G1 AChE. Also acts as an NMDA receptor antagonist. Phase 4.
M3189	TCN-201	TCN 201 is a NMDA receptor antagonist for NR1/NR2A and NR1/NR2B with pIC50 of 6.8 and 4.3, respectively.
M3126	VU 0357121	VU0357121 is a novel positive allosteric modulator (PAM) of mGlu5 with EC50 of 33 nM, is inactive or very weakly antagonizing at other mGlu receptor subtypes.
M3125	VU 0364770	VU 0364770 is a positive allosteric modulator(PAM) of mGlu4 with EC50 of 1.1 μM, exhibits insignificant activity at 68 other receptors, including other mGlu subtypes.
M3124	VU 0364439	VU 0364439 is a mGlu4 positive allosteric modulator (PAM), with EC50 of 19.8 nM.
M3003	CB-839	CB-839 is a potent, selective, and orally bioavailable glutaminase inhibitor with IC50 of 24 nM for recombinant human GAC.
M2949	Piracetam	Piracetam is a cyclic derivative of the neurotransmitter gamma-aminobutyric acid (GABA), used in treatment of a wide range of cognitive disorders.
M2884	NMDA	NMDA（N-Methyl-D-aspartic acid）is a specific agonist for NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor.
M2867	MPEP hydrochloride	MPEP hydrochloride is a selective mGlu5 receptor antagonist with IC50 of 36 nM, exhibits no appreciable activity at mGlu1b/2/3/4a/7b/8a/6 receptors.
M2855	MK 801 Maleate	MK-801 is a potent, selective and non-competitive NMDA receptor antagonist with K_d of 37.2 nM in rat brain membranes.
M2767	Ifenprodil Tartrate	Ifenprodil is an atypical noncompetitive antagonist at the NMDA receptor, it interacts with high affinity at a homogeneous population of NMDA receptors in neonatal rat forebrain with IC50 of 0.3 μM.
M2766	IEM 1754 dihydrobromide	IEM 1754 dihydrobroMide is a selective AMPA/kainate receptor blockers for GluR1 and GluR3 with IC50 of 6 μM.
M2646	Dizocilpine	Dizocilpine (MK-801) is a potent N-methyl-D-aspartate (NMDA) receptor antagonist with K_i of 30.5 nM.
M2581	Ampalex	Ampalex is an ampakine and nootropic that acts as an AMPA receptor positive allosteric modulator as a treatment for Alzheimer's disease, schizophrenia and mild cognitive impairment (MCI).
M2576	VU 0361737	VU 0361737 is a selective positive allosteric modulator (PAM) for mGlu4 receptor with EC50 of 240 nM and 110 nM at human and rat receptors, respectively.
M2542	CTEP	CTEP (RO4956371) is a novel, long-acting, orally bioavailable allosteric antagonist of mGlu5 receptor with IC50 of 2.2 nM, shows >1000-fold selectivity over other mGlu receptors.
M2253	Felbamate	Felbamate is an anticonvulsant, acting as an antagonist at the NMDA-associated glycine binding site.
M1926	LY404039	LY404039 is a potent agonist of recombinant human mGlu2, mGlu3 receptors with Ki of 149 nM, 92 nM respectively.

Signaling Pathways

Product Type

GluR Glutamate receptor

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