Free shipping on all orders over $ 500

Etoposide (VP-16-213)

Cat. No. M2326
Etoposide (VP-16-213) Structure

VP-16-213; Vepesid; NSC 141540

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mM*1mL in DMSO USD 50  USD50 In stock
50mg USD 30  USD30 In stock
100mg USD 45  USD45 In stock
200mg USD 75  USD75 In stock
500mg USD 145  USD145 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Etoposide (VP-16-213) is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II inhibition activity. Etoposide caused an increase in the mean fluorescence intensity of FasR in both subclones, and an induction of FasL in the ES subclone. Etoposide phosphate is rapidly absorbed and converted to etoposide. Bioavailability averages 68% at doses up to 150 mg/m2/day.

Product Citations
Customer Product Validations & Biological Datas
Source Gene (2015) . Figure .etoposide (Abmole, Shanghai, China)
Method Real time PCR and Western blot
Cell Lines tissue(testis)
Concentrations 0, 30, 60, 90, 120 μM
Incubation Time 0, 6, 12, 18, and 24 h
Results "Es-ADAM10 may be involved in the defense process in vivo at low etoposide concentrations, by the inhibition of spermatid apoptosis. However, Es-ADAM10 might also participate in the regulation of sperm quality. The Es-ADAM10 protein accumulated with etoposide concentration increasing (Fig. 8B). In addition, Es-ADAM10 reached peak at both the mRNA (Fig. 8C) and protein (Fig. 8D) levels after 12 h with 90 μM etoposide, indicating that etoposide induced EsADAM10 in a time- and concentration-dependent manner."
Chemical Information
Molecular Weight 588.56
Formula C29H32O13
CAS Number 33419-42-0
Solubility (25°C) DMSO 42 mg/mL
Storage -20°C, protect from light, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Chyuan-Chuan Wu, et al. Structural basis of type II topoisomerase inhibition by the anticancer drug etoposide

[2] K R Hande. Etoposide: four decades of development of a topoisomerase II inhibitor

[3] N C Phillips. Oral etoposide

[4] R A Fleming, et al. Etoposide: an update

[5] K R Hande. Etoposide pharmacology

Related Topoisomerase Products

F14512 is a polyamine-containing inhibitor of DNA topoisomerase II with a broad spectrum of antitumor activities.


ICRF-193 is an TopoII inhibitor.

Topoisomerase II inhibitor 15

Topoisomerase II inhibitor 15 is a Topoisomerase II inhibitor.

Topoisomerase II inhibitor 13

Topoisomerase II inhibitor 13 is a topoisomerase II (Topo II) inhibitor.


ICRF-196 is an racemic mixture of the (S,S)- and (R,R)-isomers of ICRF-193.

Abmole Inhibitor Catalog

Keywords: Etoposide (VP-16-213), VP-16-213; Vepesid; NSC 141540 supplier, Topoisomerase, inhibitors, activators

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.