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Topoisomerase Topoisomerase

Inhibitors

Cat.No.  Name Information
M1969 Doxorubicin HCL Doxorubicin HCl is an anthracycline antibiotic that inhibits DNA topoisomerase II used in cancer chemotherapy.
M2326 Etoposide Etoposide is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II inhibition activity.
M4465 Irinotecan Irinotecan is an inhibitor of Topoisomerase I, and is is activated by hydrolysis to SN-38 (the active metabolite of Irinotecan).
M3493 Mitoxantrone Mitoxantrone is a type II topoisomerase inhibitor with IC50 of 2.0 μM, 0.42 mM for HepG2 and MCF-7/wt cells, respectively
M2144 Topotecan hydrochloride Topotecan hydrochloride is a topoisomerase I inhibitor and an apoptosis inducer.
M11039 Pyrazoloacridine Pyrazoloacridine (NSC 366140) has anticancer activity, inhibiting the activity of topoisomerases 1 and 2 (topoisomerases 1 and 2). Pyrazoloacridine (NSC 366140) on K562 in myeloid leukemia cells IC50 The value is 1.25 μM (24 h).
M10993 Berberine chloride hydrate Berberine chloride hydrate (Natural Yellow 18 chloride hydrate) is an alkaloid commonly used as an antibiotic. Berberine chloride hydrate induces reactive oxygen species (ROS) production and inhibits DNA topoisomerase. Anti-tumor properties.
M10875 PluriSIn #2 PluriSIn #2 is a selective transcriptional inhibitor of topoisomerase II α (TOP2A). PluriSIn #2 is a compound that selectively eliminates undifferentiated human pluripotent stem cells (hPSCs).
M10847 LMP744 hydrochloride LMP744 hydrochloride (MJ-III65 hydrochloride) is a DNA chimeric agent that is an inhibitor of topoisomerase 1 (Top1) with antitumor activity.
M10542 Alternariol Alternariol is a mycotoxin produced by Alternaria species. Alternariol inhibits the catalytic activity of topoisomerase I and topoisomerase II enzymes.
M10407 PNU-159682 PNU-159682 is a major active metabolite of nemorubicin (MMDX) in human liver microsomes, it is a highly potent DNA topoisomerase I inhibitor with excellent cytotoxicity. PNU-159682 is a potent ADCs cytotoxin.
M9695 Ellipticine hydrochloride Ellipticine (NSC 71795) hydrochloride is a potent antineoplastic agent which inhibits DNA topoisomerase II activities.
M9101 Exatecan mesylate Exatecan Mesylate is a water soluble topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL).
M9023 Ellipticine Ellipticine is a DNA intercalating agent and a DNA topoisomerase II inhibitor.
M8877 Pixantrone Maleate Pixantrone dimaleate is a topoisomerase II inhibitor and DNA intercalator, with anti-tumor activity.
M7507 10-Hydroxycamptothecin 10-Hydroxycamptothecin is a cell-permeable powerful DNA topoisomerase I inhibitor. It has selective inhibitory effect on the phosphorylation of histone H1 and H3, but less effect on other histones.
M7505 7-Ethylcamptothecin 7-Ethyl Camptothecin is an anti-cancer chemical that exhibits a strong activity against various murine tumors through Topo I (topoisomerase) inhibition.
M5882 Pirarubicin HCl Pirarubicin Hcl is an analogue of the anthracycline anti-neoplastic doxorubicin, which is an inhibitor of Topo II.
M5832 Ofloxacin Ofloxacin is a synthetic broad-spectrum antimicrobial agent.
M5825 Novobiocin Sodium Novobiocin Sodium is an aminocoumarin antibiotic that targets bacterial DNA gyrase (TopoIV), used to treat susceptible gram positive bacteria.
M5823 Norfloxacin Norfloxacin is a broad-spectrum antibiotic.
M5821 Nitroxoline Nitroxoline is a urinary antibacterial agent active against susceptible gram-positive and gram-negative organisms commonly found in urinary tract infections. It is a fluorquinolone that is active against bacterial gyrases.
M5737 Levofloxacin hydrate Levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. It acts by inhibiting DNA gyrase (bacterial topoisomerase II).
M5711 Irinotecan hydrochloride Irinotecan prevents DNA from unwinding by inhibition of topoisomerase 1.
M5617 Epirubicin HCl Epirubicin Hcl, a semisynthetic L-arabino derivative of doxorubicin, is an antineoplastic agent by inhibiting Topoisomerase.



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