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Topoisomerase Topoisomerase

Cat.No.  Name Information
M4903 Ciprofloxacin Ciprofloxacin is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity, with MIC90 of 0.024-6 μM.
M4465 Irinotecan Irinotecan is an inhibitor of Topoisomerase I, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex. Irinotecan inhibits the growth of LoVo and HT-29 cells, with IC50s of 15.8 ± 5.1 and 5.17 ± 1.4 μM, respectively.
M3514 Moxifloxacin hydrochloride Moxifloxacin is a fourth-generation synthetic fluoroquinolone antibacterial agent.
M3493 Mitoxantrone Mitoxantrone is a type II topoisomerase inhibitor with IC50 of 2.0 μM, 0.42 mM for HepG2 and MCF-7/wt cells, respectively
M3016 SN-38 SN-38 is an active metabolite of CPT-11, inhibits DNA topoisomerase I, DNA synthesis and causes frequent DNA single-strand breaks.
M2326 Etoposide (VP-16-213) Etoposide (VP-16-213) is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II inhibition activity.
M2265 Pirarubicin Pirarubicin is an anthracycline that is an inhibitor of Topoisomerase II.*The compound is unstable in solutions, freshly prepared is recommended
M2199 Camptothecin Camptothecin (CPT), an alkaloid, is an inhibitor of DNA Topoisomerase I (Topo I) with an IC50 value of 679 nM. Camptothecin (CPT) has strong antitumor activity against colorectal cancer, breast cancer, lung cancer and ovarian cancer, and modulates hypoxia-inducible factor-1α (HIF-1α) activity by altering miRNA expression patterns in human cancer cells.
M2144 Topotecan hydrochloride Topotecan hydrochloride is a topoisomerase I inhibitor and an apoptosis inducer.
M2001 Idarubicin Idarubicin is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells.
M55211 F14512 F14512 is a polyamine-containing inhibitor of DNA topoisomerase II with a broad spectrum of antitumor activities.
M41618 Cholesteryl hemisuccinate Cholesteryl hemisuccinate is a with hepatoprotective an anticancer activity.
M25388 9-Aminocamptothecin 9-Aminocamptothecin (9-amino-CPT) is a topoisomerase I inhibitor with potent anticancer activity. 9-Aminocamptothecin inhibits PC-3, PC-3M, DU145, and LNCaP cells with IC50 values of 34.1, 10, 6.5, and 8.9 nM, respectively after 96 h exposure.
M22169 Daunorubicin Daunorubicin (Daunomycin) is a topoisomerase II inhibitor, it inhibits DNA and RNA synthesis. Daunorubicin is also an anthracycline antibiotic, which can be used in the research of infection and variety of cancers.
M20696 Rubitecan Rubitecan is a topoisomerase I inhibitor extracted from the bark and leaves of the Camptotheca acuminata tree, which is native to China. Rubitecan is an oral camptothecin with antitumour activity.
M20401 (S)-10-Hydroxycamptothecin 10-Hydroxycamptothecin is a DNA topoisomerase I inhibitor with potent anti-tumor activity.
M19867 Gatifloxacin hydrochloride Gatifloxacin (AM-1155, CG5501, BMS-206584, PD135432) hydrochloride is a potent fluoroquinolone antibiotic with broad-spectrum antibacterial activity. Gatifloxacin hydrochloride inhibits bacterial type II topoisomerases with IC50 of 13.8 μg/ml and 0.109 μg/ml for S. aureus topoisomerase IV and E. coli DNA gyrase, respectively.
M19284 Topotecan Topotecan (SKF 104864A; NSC 609669) is an orally active and potent Topoisomerase I inhibitor. Topotecan induces cell cycle arrest in G0/G1 and S phases and promotes apoptosis. Topotecan shows anticancer activity.
M13744 Dxd Dxd (Exatecan derivative for ADC) is a potent DNA topoisomerase I inhibitor, with an IC50 of 0.31 μM, used as a conjugated drug of HER2-targeting ADC (DS-8201a).
M13743 Daun02 Daun02 is a prodrug of the topoisomerase inhibitor Daunorubicin.

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