Inhibitors
Cat.No. | Name | Information |
---|---|---|
M1969 | Doxorubicin HCL | Doxorubicin HCl is an anthracycline antibiotic that inhibits DNA topoisomerase II used in cancer chemotherapy. |
M2326 | Etoposide | Etoposide is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II inhibition activity. |
M4465 | Irinotecan | Irinotecan is an inhibitor of Topoisomerase I, and is is activated by hydrolysis to SN-38 (the active metabolite of Irinotecan). |
M3493 | Mitoxantrone | Mitoxantrone is a type II topoisomerase inhibitor with IC50 of 2.0 μM, 0.42 mM for HepG2 and MCF-7/wt cells, respectively |
M2144 | Topotecan hydrochloride | Topotecan hydrochloride is a topoisomerase I inhibitor and an apoptosis inducer. |
M11039 | Pyrazoloacridine | Pyrazoloacridine (NSC 366140) has anticancer activity, inhibiting the activity of topoisomerases 1 and 2 (topoisomerases 1 and 2). Pyrazoloacridine (NSC 366140) on K562 in myeloid leukemia cells IC50 The value is 1.25 μM (24 h). |
M10993 | Berberine chloride hydrate | Berberine chloride hydrate (Natural Yellow 18 chloride hydrate) is an alkaloid commonly used as an antibiotic. Berberine chloride hydrate induces reactive oxygen species (ROS) production and inhibits DNA topoisomerase. Anti-tumor properties. |
M10875 | PluriSIn #2 | PluriSIn #2 is a selective transcriptional inhibitor of topoisomerase II α (TOP2A). PluriSIn #2 is a compound that selectively eliminates undifferentiated human pluripotent stem cells (hPSCs). |
M10847 | LMP744 hydrochloride | LMP744 hydrochloride (MJ-III65 hydrochloride) is a DNA chimeric agent that is an inhibitor of topoisomerase 1 (Top1) with antitumor activity. |
M10542 | Alternariol | Alternariol is a mycotoxin produced by Alternaria species. Alternariol inhibits the catalytic activity of topoisomerase I and topoisomerase II enzymes. |
M10407 | PNU-159682 | PNU-159682 is a major active metabolite of nemorubicin (MMDX) in human liver microsomes, it is a highly potent DNA topoisomerase I inhibitor with excellent cytotoxicity. PNU-159682 is a potent ADCs cytotoxin. |
M9695 | Ellipticine hydrochloride | Ellipticine (NSC 71795) hydrochloride is a potent antineoplastic agent which inhibits DNA topoisomerase II activities. |
M9101 | Exatecan mesylate | Exatecan Mesylate is a water soluble topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL). |
M9023 | Ellipticine | Ellipticine is a DNA intercalating agent and a DNA topoisomerase II inhibitor. |
M8877 | Pixantrone Maleate | Pixantrone dimaleate is a topoisomerase II inhibitor and DNA intercalator, with anti-tumor activity. |
M7507 | 10-Hydroxycamptothecin | 10-Hydroxycamptothecin is a cell-permeable powerful DNA topoisomerase I inhibitor. It has selective inhibitory effect on the phosphorylation of histone H1 and H3, but less effect on other histones. |
M7505 | 7-Ethylcamptothecin | 7-Ethyl Camptothecin is an anti-cancer chemical that exhibits a strong activity against various murine tumors through Topo I (topoisomerase) inhibition. |
M5882 | Pirarubicin HCl | Pirarubicin Hcl is an analogue of the anthracycline anti-neoplastic doxorubicin, which is an inhibitor of Topo II. |
M5832 | Ofloxacin | Ofloxacin is a synthetic broad-spectrum antimicrobial agent. |
M5825 | Novobiocin Sodium | Novobiocin Sodium is an aminocoumarin antibiotic that targets bacterial DNA gyrase (TopoIV), used to treat susceptible gram positive bacteria. |
M5823 | Norfloxacin | Norfloxacin is a broad-spectrum antibiotic. |
M5821 | Nitroxoline | Nitroxoline is a urinary antibacterial agent active against susceptible gram-positive and gram-negative organisms commonly found in urinary tract infections. It is a fluorquinolone that is active against bacterial gyrases. |
M5737 | Levofloxacin hydrate | Levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. It acts by inhibiting DNA gyrase (bacterial topoisomerase II). |
M5711 | Irinotecan hydrochloride | Irinotecan prevents DNA from unwinding by inhibition of topoisomerase 1. |
M5617 | Epirubicin HCl | Epirubicin Hcl, a semisynthetic L-arabino derivative of doxorubicin, is an antineoplastic agent by inhibiting Topoisomerase. |
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