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Gatifloxacin hydrochloride

Cat. No. M19867
Gatifloxacin hydrochloride Structure
Synonym:

AM-1155 hydrochloride; CG5501 hydrochloride; BMS-206584 hydrochloride; PD135432 hydrochloride

Size Price Availability Quantity
50mg USD 48  USD60 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Gatifloxacin (AM-1155, CG5501, BMS-206584, PD135432) hydrochloride is a potent fluoroquinolone antibiotic with broad-spectrum antibacterial activity. Gatifloxacin hydrochloride inhibits bacterial type II topoisomerases with IC50 of 13.8 μg/ml and 0.109 μg/ml for S. aureus topoisomerase IV and E. coli DNA gyrase, respectively.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 411.86
Formula C19H23ClFN3O4
CAS Number 121577-32-0
Purity >99%
Solubility DMSO 4 mg/mL
Water 20 mg/mL
Storage at -20°C
References

[1] Saravanakumar Arthanari, et al. Artif Cells Nanomed Biotechnol. Preparation and characterization of gatifloxacin-loaded alginate/poly (vinyl alcohol) electrospun nanofibers

[2] Namrata Sharma, et al. Eye Contact Lens. Evaluation of 0.3% gatifloxacin hydrochloride in decontamination of donor corneas

[3] Eun Ju Lee, et al. Bioprocess Biosyst Eng. Studies on the characteristics of drug-loaded gelatin nanoparticles prepared by nanoprecipitation

[4] Joel W Proksch, et al. J Ocul Pharmacol Ther. Ocular pharmacokinetics/pharmacodynamics of besifloxacin, moxifloxacin, and gatifloxacin following topical administration to pigmented rabbits

[5] M Bayes, et al. Methods Find Exp Clin Pharmacol. Gateways to Clinical Trials. June 2002

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Keywords: Gatifloxacin hydrochloride, AM-1155 hydrochloride; CG5501 hydrochloride; BMS-206584 hydrochloride; PD135432 hydrochloride supplier, Topoisomerase, inhibitors

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