Gatifloxacin (AM-1155, CG5501, BMS-206584, PD135432) hydrochloride is a potent fluoroquinolone antibiotic with broad-spectrum antibacterial activity. Gatifloxacin hydrochloride inhibits bacterial type II topoisomerases with IC50 of 13.8 μg/ml and 0.109 μg/ml for S. aureus topoisomerase IV and E. coli DNA gyrase, respectively.
|Solubility (25°C)||DMSO 4 mg/mL
Water 20 mg/mL
Powder -20°C 3 years ; 4°C 2 years
In solvent -80°C 6 months ; -20°C 1 month
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
 Saravanakumar Arthanari, et al. Artif Cells Nanomed Biotechnol. Preparation and characterization of gatifloxacin-loaded alginate/poly (vinyl alcohol) electrospun nanofibers
 Namrata Sharma, et al. Eye Contact Lens. Evaluation of 0.3% gatifloxacin hydrochloride in decontamination of donor corneas
 Eun Ju Lee, et al. Bioprocess Biosyst Eng. Studies on the characteristics of drug-loaded gelatin nanoparticles prepared by nanoprecipitation
 Joel W Proksch, et al. J Ocul Pharmacol Ther. Ocular pharmacokinetics/pharmacodynamics of besifloxacin, moxifloxacin, and gatifloxacin following topical administration to pigmented rabbits
 M Bayes, et al. Methods Find Exp Clin Pharmacol. Gateways to Clinical Trials. June 2002
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