About 34 results found for searched term "Topoisomerase" (0.063 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M41609 | Topoisomerase II inhibitor 16 | Topoisomerase |
| Topoisomerase II inhibitor 16 is a selective, orally active, brain-penetrant and irreversible trypanosomal topoisomerase II inhibitor by stabilizing double-stranded DNA:enzyme cleavage complexes. | ||
| M41613 | Topoisomerase II inhibitor 14 | Topoisomerase |
| Topoisomerase II inhibitor 14 is a potent inhibtor of Topoisomerase II, with anticancer activity. | ||
| M41620 | Topoisomerase II inhibitor 13 | Topoisomerase |
| Topoisomerase II inhibitor 13 is a topoisomerase II (Topo II) inhibitor. | ||
| M41621 | Topoisomerase II inhibitor 15 | Topoisomerase |
| Topoisomerase II inhibitor 15 is a Topoisomerase II inhibitor. | ||
| M1969 | Doxorubicin HCL | Animal Modeling |
| RP 13057 hydrochloride; Adriamycin; Rubex; DOX | ||
| Doxorubicin HCl (Adriamycin, DOX, RP 13057) hydrochloride is an antibiotic-like agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis. | ||
| M2001 | Idarubicin | Topoisomerase |
| Idarubicin is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells. | ||
| M2089 | Irinotecan Hydrochloride Trihydrate | Topoisomerase |
| Campto, CPT-11 | ||
| Irinotecan hydrochloride trihydrate is a potent inhibitor of DNA topoisomerase I. | ||
| M2144 | Topotecan hydrochloride | Topoisomerase |
| Hycamtin; NSC 609669; SKF 104864A hydrochloride | ||
| Topotecan hydrochloride is a topoisomerase I inhibitor and an apoptosis inducer. | ||
| M2199 | Camptothecin | Topoisomerase |
| Camptothecine; (S)-(+)-Camptothecin; CPT | ||
| Camptothecin (CPT), an alkaloid, is an inhibitor of DNA Topoisomerase I (Topo I) with an IC50 value of 679 nM. Camptothecin (CPT) has strong antitumor activity against colorectal cancer, breast cancer, lung cancer and ovarian cancer, and modulates hypoxia-inducible factor-1α (HIF-1α) activity by altering miRNA expression patterns in human cancer cells. | ||
| M2217 | Mitoxantrone dihydrochloride | Topoisomerase |
| Mitozantrone dihydrochloride; NSC 301739 dihydrochloride | ||
| Mitoxantrone dihydrochloride is a potent topoisomerase II inhibitor. Mitoxantrone dihydrochloride also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM. | ||
| M2252 | Ellagic acid | Topoisomerase |
| Ellagic acid is a natural antioxidant as well as a potent, ATP-competitive inhibitor of CK2 and SHP2 with IC50 and Ki values of 40 nM and 20 nM, respectively.In addition, Ellagic acid exhibits antiproliferative activity and inhibition of topoisomerase II (Topoisomerase II). | ||
| M2265 | Pirarubicin | Topoisomerase |
| THP-Adriamycin | ||
| Pirarubicin is an anthracycline that is an inhibitor of Topoisomerase II.*The compound is unstable in solutions, freshly prepared is recommended | ||
| M2326 | Etoposide (VP-16-213) | Topoisomerase |
| VP-16-213; Vepesid; NSC 141540 | ||
| Etoposide (VP-16-213) is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II inhibition activity. | ||
| M2327 | Daunorubicin hydrochloride | DNA/RNA Synthesis |
| Daunomycin hydrochloride; RP 13057 hydrochloride; Rubidomycin hydrochloride | ||
| Daunorubicin (Daunomycin) HCl is a topoisomerase II inhibitor, inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM. Daunorubicin hydrochloride is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin hydrochloride is also an anthracycline antibiotic. | ||
| M2453 | β-Lapachone | Topoisomerase |
| ARQ-501; NSC-26326 | ||
| β-Lapachone is a selective DNA topoisomerase I inhibitor, exhibiting no inhibitory activities against DNA topoisomerase II or ligase. | ||
| M2526 | Clinafloxacin | Antibiotic |
| CI-960, PD127391, AM-1091 | ||
| Clinafloxacin is a fluoroquinolone that inhibits both DNA gyrase and topoisomerase IV dually in Streptococcus pneumoniae. | ||
| M2707 | Flumequine | Topoisomerase |
| R-802 | ||
| Flumequine is a synthetic chemotherapeutic antibiotic, inhibiting topoisomerase II with IC50 of 15 μM. | ||
| M2918 | Pefloxacin Mesylate Dihydrate | Topoisomerase |
| Pefloxacinium mesylate dihydrate | ||
| Pefloxacin Mesylate Dihydrate is the third generation of fluoroquinolone class of antibacterials, which inhibits Topoisomerase II activity and DNA replication. | ||
| M3016 | SN-38 | Topoisomerase |
| NK012; 7-ethyl-10-hydroxycamtothecin | ||
| SN-38 is an active metabolite of CPT-11, inhibits DNA topoisomerase I, DNA synthesis and causes frequent DNA single-strand breaks. | ||
| M3161 | Betulinic acid | NF-κB |
| Lupatic acid; Betulic acid | ||
| Betulinic acid is a natural pentacyclic triterpenoid compound, which is an inhibitor of eukaryotic cell topoisomerase I with IC50 value of 5 μM. It has anti-inflammatory, anti-malaria, anti-AIDS and anti-tumor activities. Betulinic acid(Betulinic acid) is also an agonist of 20S proteasome. EC50=5.5μmol/L, Betulinic acid can specifically enhance cT-L activity of 20S proteasome. | ||
| M3493 | Mitoxantrone | Topoisomerase |
| Mitozantrone; NSC 301739 | ||
| Mitoxantrone is a type II topoisomerase inhibitor with IC50 of 2.0 μM, 0.42 mM for HepG2 and MCF-7/wt cells, respectively | ||
| M3697 | Amrubicin | Topoisomerase |
| SM-5887 | ||
| Amrubicin is a third-generation anthracycline and potent topoisomerase II inhibitor, showed promising activity in small-cell lung cancer (SCLC) in phase II trials. | ||
| M3784 | Genz-644282 | Topoisomerase |
| Genz 644282 is a novel non-camptothecin topoisomerase I inhibitor with an IC50 value of 0.4 nM in human bone marrow CFU-GM assay. | ||
| M3990 | Betulonic acid | Parasite |
| Betunolic acid; Liquidambaric acid; (+)-Betulonic acid | ||
| Betulinic acid (Betulinic acid) is an inhibitor of eukaryotic cell topoisomerase I with IC50 value of 5 μM. It has anti-inflammatory, anti-malaria, anti-AIDS and anti-tumor activities. Betulinic acid is also a new nF-KB agonist. | ||
| M4403 | Groenlandicine | Topoisomerase |
| Groenlandicine is a proto berberine alkaloid isolated from coptis chinensis. Groenlandicine has moderate inhibition of human recombinant aldose reductase (HRAR) with an IC50 value of 154.2 μM. Groenlandicine induces DNA cleavage mediated by topoisomerase I. | ||
| M4465 | Irinotecan | Topoisomerase |
| (+)-Irinotecan; CPT-11; VAL-413 | ||
| Irinotecan is an inhibitor of Topoisomerase I, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex. Irinotecan inhibits the growth of LoVo and HT-29 cells, with IC50s of 15.8 ± 5.1 and 5.17 ± 1.4 μM, respectively. | ||
| M4860 | Idarubicin HCl | Topoisomerase |
| Idarubicin HCl is a hydrochloride salt form of Idarubicin which is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells with IC50 of 3.3 ng/mL in a cell-free assay. | ||
| M5617 | Epirubicin hydrochloride | Topoisomerase |
| 4'-Epidoxorubicin hydrochloride; Epirubicin HCl | ||
| Epirubicin hydrochloride, a semisynthetic L-arabino derivative of doxorubicin, is an antineoplastic agent by inhibiting Topoisomerase. Epirubicin hydrochloride inhibits DNA and RNA synthesis. Epirubicin hydrochloride is a Forkhead box protein p3 (Foxp3) inhibitor and inhibits regulatory T cell activity. | ||
| M5711 | Irinotecan hydrochloride | Topoisomerase |
| CPT-11 HCl | ||
| Irinotecan hydrochloride ((+)-Irinotecan hydrochloride) is a topoisomerase I inhibitor. Irinotecan prevents DNA from unwinding by inhibition of topoisomerase 1. | ||
| M5737 | Levofloxacin hydrate | Topoisomerase |
| Levofloxacin hemihydrate, Levaquin hydrate | ||
| Levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. It acts by inhibiting DNA gyrase (bacterial topoisomerase II). | ||
| M7505 | 7-Ethylcamptothecin | Topoisomerase |
| 7-Ethyl Camptothecin is an anti-cancer chemical that exhibits a strong activity against various murine tumors through Topo I (topoisomerase) inhibition. | ||
| M7507 | 10-Hydroxycamptothecin | Topoisomerase |
| Hydroxy Camptothecine | ||
| 10-Hydroxycamptothecin is a cell-permeable powerful DNA topoisomerase I inhibitor. It has selective inhibitory effect on the phosphorylation of histone H1 and H3, but less effect on other histones. | ||
| M25614 | Gepotidacin | Topoisomerase |
| GSK2140944 | ||
| Gepotidacin (GSK2140944) is a novel, potentially first-in-class, orally active triazaacenaphthylene antibiotic and type II topoisomerase (Topo II) inhibitor.Gepotidacin can selectively inhibit bacterial DNA replication by acting on DNA gyrase (GyrA) and topoisomerase IV (ParC). | ||
| M10542 | Alternariol | Topoisomerase |
| Alternariol is a mycotoxin produced by Alternaria species. Alternariol inhibits the catalytic activity of topoisomerase I and topoisomerase II enzymes. | ||
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