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 About 34 results found for searched term "Topoisomerase" (0.182 seconds)

Cat.No.  Name Target
M41609 Topoisomerase II inhibitor 16 Topoisomerase
Topoisomerase II inhibitor 16 is a selective, orally active, brain-penetrant and irreversible trypanosomal topoisomerase II inhibitor by stabilizing double-stranded DNA:enzyme cleavage complexes.
M41613 Topoisomerase II inhibitor 14 Topoisomerase
Topoisomerase II inhibitor 14 is a potent inhibtor of Topoisomerase II, with anticancer activity.
M41620 Topoisomerase II inhibitor 13 Topoisomerase
Topoisomerase II inhibitor 13 is a topoisomerase II (Topo II) inhibitor.
M41621 Topoisomerase II inhibitor 15 Topoisomerase
Topoisomerase II inhibitor 15 is a Topoisomerase II inhibitor.
M1969 Doxorubicin HCL Animal Modeling
RP 13057 hydrochloride; Adriamycin; Rubex;DOX
Doxorubicin HCl (Adriamycin, DOX, RP 13057) hydrochloride is an antibiotic-like agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis.
M2001 Idarubicin Topoisomerase
Idarubicin is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells.
M2089 Irinotecan Hydrochloride Trihydrate Topoisomerase
Campto, CPT-11
Irinotecan hydrochloride trihydrate is a potent inhibitor of DNA topoisomerase I.
M2144 Topotecan hydrochloride Topoisomerase
Hycamtin, NSC 609669
Topotecan hydrochloride is a topoisomerase I inhibitor and an apoptosis inducer.
M2199 Camptothecin Topoisomerase
Camptothecine; (S)-(+)-Camptothecin; CPT
Camptothecin (CPT), an alkaloid, is an inhibitor of DNA Topoisomerase I (Topo I) with an IC50 value of 679 nM. Camptothecin (CPT) has strong antitumor activity against colorectal cancer, breast cancer, lung cancer and ovarian cancer, and modulates hypoxia-inducible factor-1α (HIF-1α) activity by altering miRNA expression patterns in human cancer cells.
M2217 Mitoxantrone dihydrochloride Topoisomerase
mitozantrone dihydrochloride
Mitoxantrone dihydrochloride is a potent inhibitor of topoisomerase II.
M2252 Ellagic acid Topoisomerase
Ellagic acid is a natural antioxidant as well as a potent, ATP-competitive inhibitor of CK2 and SHP2 with IC50 and Ki values of 40 nM and 20 nM, respectively.In addition, Ellagic acid exhibits antiproliferative activity and inhibition of topoisomerase II (Topoisomerase II).
M2265 Pirarubicin Topoisomerase
THP-Adriamycin
Pirarubicin is an anthracycline that is an inhibitor of Topoisomerase II.*The compound is unstable in solutions, freshly prepared is recommended
M2326 Etoposide (VP-16-213) Topoisomerase
VP-16-213; Vepesid; NSC 141540
Etoposide (VP-16-213) is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II inhibition activity.
M2327 Daunorubicin hydrochloride DNA/RNA Synthesis
Daunomycin hydrochloride; RP 13057 hydrochloride; Rubidomycin hydrochloride
Daunorubicin (Daunomycin) HCl is a topoisomerase II inhibitor, inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM. Daunorubicin hydrochloride is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin hydrochloride is also an anthracycline antibiotic.
M2453 β-Lapachone Topoisomerase
ARQ-501; NSC-26326
β-Lapachone is a selective DNA topoisomerase I inhibitor, exhibiting no inhibitory activities against DNA topoisomerase II or ligase.
M2526 Clinafloxacin Antibiotic
CI-960, PD127391, AM-1091
Clinafloxacin is a fluoroquinolone that inhibits both DNA gyrase and topoisomerase IV dually in Streptococcus pneumoniae.
M2707 Flumequine Topoisomerase
Flumequine is a synthetic chemotherapeutic antibiotic, inhibiting topoisomerase II with IC50 of 15 μM.
M2918 Pefloxacin Mesylate Dihydrate Topoisomerase
Pefloxacinium mesylate dihydrate
Pefloxacin Mesylate Dihydrate is the third generation of fluoroquinolone class of antibacterials, which inhibits Topoisomerase II activity and DNA replication.
M3016 SN-38 Topoisomerase
NK012
SN-38 is an active metabolite of CPT-11, inhibits DNA topoisomerase I, DNA synthesis and causes frequent DNA single-strand breaks.
M3161 Betulinic acid NF-κB
Lupatic acid; Betulic acid
Betulinic acid is a natural pentacyclic triterpenoid compound, which is an inhibitor of eukaryotic cell topoisomerase I with IC50 value of 5 μM. It has anti-inflammatory, anti-malaria, anti-AIDS and anti-tumor activities. Betulinic acid(Betulinic acid) is also an agonist of 20S proteasome. EC50=5.5μmol/L, Betulinic acid can specifically enhance cT-L activity of 20S proteasome.
M3493 Mitoxantrone Topoisomerase
Mitozantrone
Mitoxantrone is a type II topoisomerase inhibitor with IC50 of 2.0 μM, 0.42 mM for HepG2 and MCF-7/wt cells, respectively
M3697 Amrubicin Topoisomerase
SM-5887
Amrubicin is a third-generation anthracycline and potent topoisomerase II inhibitor, showed promising activity in small-cell lung cancer (SCLC) in phase II trials.
M3784 Genz-644282 Topoisomerase
Genz 644282 is a novel non-camptothecin topoisomerase I inhibitor with an IC50 value of 0.4 nM in human bone marrow CFU-GM assay.
M3990 Betulonic acid Parasite
Betunolic acid; Liquidambaric acid; (+)-Betulonic acid
Betulinic acid (Betulinic acid) is an inhibitor of eukaryotic cell topoisomerase I with IC50 value of 5 μM. It has anti-inflammatory, anti-malaria, anti-AIDS and anti-tumor activities. Betulinic acid is also a new nF-KB agonist.
M4403 Groenlandicine Topoisomerase
Groenlandicine is a proto berberine alkaloid isolated from coptis chinensis. Groenlandicine has moderate inhibition of human recombinant aldose reductase (HRAR) with an IC50 value of 154.2 μM. Groenlandicine induces DNA cleavage mediated by topoisomerase I.
M4465 Irinotecan Topoisomerase
(+)-Irinotecan; CPT-11; VAL-413
Irinotecan is an inhibitor of Topoisomerase I, and is is activated by hydrolysis to SN-38 (the active metabolite of Irinotecan).
M4860 Idarubicin HCl Topoisomerase
Idarubicin HCl is a hydrochloride salt form of Idarubicin which is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells with IC50 of 3.3 ng/mL in a cell-free assay.
M5617 Epirubicin HCl Topoisomerase
4'-Epidoxorubicin hydrochloride
Epirubicin Hcl, a semisynthetic L-arabino derivative of doxorubicin, is an antineoplastic agent by inhibiting Topoisomerase. Epirubicin hydrochloride inhibits DNA and RNA synthesis. Epirubicin hydrochloride is a Forkhead box protein p3 (Foxp3) inhibitor and inhibits regulatory T cell activity.
M5711 Irinotecan hydrochloride Topoisomerase
CPT-11 HCl
Irinotecan prevents DNA from unwinding by inhibition of topoisomerase 1.
M5737 Levofloxacin hydrate Topoisomerase
Levofloxacin hemihydrate, Levaquin hydrate
Levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. It acts by inhibiting DNA gyrase (bacterial topoisomerase II).
M7505 7-Ethylcamptothecin Topoisomerase
7-Ethyl Camptothecin is an anti-cancer chemical that exhibits a strong activity against various murine tumors through Topo I (topoisomerase) inhibition.
M7507 10-Hydroxycamptothecin Topoisomerase
Hydroxy Camptothecine
10-Hydroxycamptothecin is a cell-permeable powerful DNA topoisomerase I inhibitor. It has selective inhibitory effect on the phosphorylation of histone H1 and H3, but less effect on other histones.
M25614 Gepotidacin Topoisomerase
GSK2140944
Gepotidacin (GSK2140944) is a novel, potentially first-in-class, orally active triazaacenaphthylene antibiotic and type II topoisomerase (Topo II) inhibitor.Gepotidacin can selectively inhibit bacterial DNA replication by acting on DNA gyrase (GyrA) and topoisomerase IV (ParC).
M10542 Alternariol Topoisomerase
Alternariol is a mycotoxin produced by Alternaria species. Alternariol inhibits the catalytic activity of topoisomerase I and topoisomerase II enzymes.



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