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SN-38

Cat. No. M3016
SN-38 Structure
Synonym:

NK012

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
50mg USD 58.5  USD65 In stock
100mg USD 85.5  USD95 In stock
200mg USD 144  USD160 In stock
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Quality Control
Biological Activity

SN-38 is an active metabolite of CPT-11, inhibits DNA topoisomerase I, DNA synthesis and causes frequent DNA single-strand breaks.

Product Citations
Customer Product Validations & Biological Datas
Source Customer experimental result (2018).
Method Cell viability assay
Cell Lines MDA-MB-231 cells
Concentrations 32nM
Incubation Time 4 days
Results MDA-MB-231 cells were treated with 32nM SN-38 for 4 days and then incubated for 4 days. Most of the MDA-MB-231 cells were transformed into senescent cells.
Source J Immunol Res (2018). Figure 1. SN-38
Method flow cytometry
Cell Lines NB cell lines
Concentrations 1 nM
Incubation Time 24 hours
Results Cisplatin at 2 μM, etoposide at 0.1 μM, irinotecan at 1 nM, and topotecan at 10nM induced apoptosis of all NB cell lines after 48 hours of treatment, with the exception of SK-N-AS treated with the first three drugs and SK-N-BE(2)c treated with all four drugs
Protocol
Cell Experiment
Cell lines A-172, U-87, and LA-567
Preparation method MTT assay
Concentrations 0 -1000 nM
Incubation time 48 h
Animal Experiment
Animal models Nontumor-bearing mice
Formulation dissolved in DMSO (1 mg/mL)
Dosages 1 mg/kg
Administration i.v.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 392.4
Formula C22H20N2O5
CAS Number 86639-52-3
Purity 99.57%
Solubility DMSO 21 mg/mL
Storage at -20°C
References

Disposition of irinotecan and SN-38 following oral and intravenous irinotecan dosing in mice.
Stewart CF, et al. Cancer Chemother Pharmacol. 1997;40(3):259-65. PMID: 9219511.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: SN-38, NK012 supplier, Topoisomerase, inhibitors

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