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SN-38 is an active metabolite of CPT-11, inhibits DNA topoisomerase I, DNA synthesis and causes frequent DNA single-strand breaks.
BMC Biol. 2021 May 20;19(1):108.
Very long intergenic non-coding (vlinc) RNAs directly regulate multiple genes in cis and trans
SN-38 purchased from AbMole
Nat Commun. 2019 Dec 20;10(1):5799.
Novel approach reveals genomic landscapes of single-strand DNA breaks with nucleotide resolution in human cells.
SN-38 purchased from AbMole
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Source | Customer experimental result (2018). |
| Method | Cell viability assay | |
| Cell Lines | MDA-MB-231 cells | |
| Concentrations | 32nM | |
| Incubation Time | 4 days | |
| Results | MDA-MB-231 cells were treated with 32nM SN-38 for 4 days and then incubated for 4 days. Most of the MDA-MB-231 cells were transformed into senescent cells. |
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Source | J Immunol Res (2018). Figure 1. SN-38 |
| Method | flow cytometry | |
| Cell Lines | NB cell lines | |
| Concentrations | 1 nM | |
| Incubation Time | 24 hours | |
| Results | Cisplatin at 2 μM, etoposide at 0.1 μM, irinotecan at 1 nM, and topotecan at 10nM induced apoptosis of all NB cell lines after 48 hours of treatment, with the exception of SK-N-AS treated with the first three drugs and SK-N-BE(2)c treated with all four drugs |
| Cell Experiment | |
|---|---|
| Cell lines | A-172, U-87, and LA-567 |
| Preparation method | MTT assay |
| Concentrations | 0 -1000 nM |
| Incubation time | 48 h |
| Animal Experiment | |
|---|---|
| Animal models | Nontumor-bearing mice |
| Formulation | dissolved in DMSO (1 mg/mL) |
| Dosages | 1 mg/kg |
| Administration | i.v. |
| Molecular Weight | 392.4 |
| Formula | C22H20N2O5 |
| CAS Number | 86639-52-3 |
| Solubility (25°C) | DMSO 21 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Topoisomerase Products |
|---|
| Amonafide
Amonafide is a unique ATP-independent Topo II inhibitor that is being studied in the treatment of cancer. |
| Camptothecin
Camptothecin (CPT), an alkaloid, is an inhibitor of DNA Topoisomerase I (Topo I) with an IC50 value of 679 nM. Camptothecin (CPT) has strong antitumor activity against colorectal cancer, breast cancer, lung cancer and ovarian cancer, and modulates hypoxia-inducible factor-1α (HIF-1α) activity by altering miRNA expression patterns in human cancer cells. |
| Ellagic acid
Ellagic acid is a natural antioxidant as well as a potent, ATP-competitive inhibitor of CK2 and SHP2 with IC50 and Ki values of 40 nM and 20 nM, respectively.In addition, Ellagic acid exhibits antiproliferative activity and inhibition of topoisomerase II (Topoisomerase II). |
| Pirarubicin
Pirarubicin is an anthracycline that is an inhibitor of Topoisomerase II.*The compound is unstable in solutions, freshly prepared is recommended |
| β-Lapachone
β-Lapachone is a selective DNA topoisomerase I inhibitor, exhibiting no inhibitory activities against DNA topoisomerase II or ligase. |
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