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SN-38

Cat. No. M3016
SN-38 Structure
Synonym:

NK012

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
50mg USD 60  USD60 In stock
100mg USD 90  USD90 In stock
200mg USD 160  USD160 In stock
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Quality Control & Documentation
Biological Activity

SN-38 is an active metabolite of CPT-11, inhibits DNA topoisomerase I, DNA synthesis and causes frequent DNA single-strand breaks.

Product Citations
Customer Product Validations & Biological Datas
Source Customer experimental result (2018).
Method Cell viability assay
Cell Lines MDA-MB-231 cells
Concentrations 32nM
Incubation Time 4 days
Results MDA-MB-231 cells were treated with 32nM SN-38 for 4 days and then incubated for 4 days. Most of the MDA-MB-231 cells were transformed into senescent cells.
Source J Immunol Res (2018). Figure 1. SN-38
Method flow cytometry
Cell Lines NB cell lines
Concentrations 1 nM
Incubation Time 24 hours
Results Cisplatin at 2 μM, etoposide at 0.1 μM, irinotecan at 1 nM, and topotecan at 10nM induced apoptosis of all NB cell lines after 48 hours of treatment, with the exception of SK-N-AS treated with the first three drugs and SK-N-BE(2)c treated with all four drugs
Protocol (for reference only)
Cell Experiment
Cell lines A-172, U-87, and LA-567
Preparation method MTT assay
Concentrations 0 -1000 nM
Incubation time 48 h
Animal Experiment
Animal models Nontumor-bearing mice
Formulation dissolved in DMSO (1 mg/mL)
Dosages 1 mg/kg
Administration i.v.
Chemical Information
Molecular Weight 392.4
Formula C22H20N2O5
CAS Number 86639-52-3
Solubility (25°C) DMSO 21 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Stewart CF, et al. Cancer Chemother Pharmacol. Disposition of irinotecan and SN-38 following oral and intravenous irinotecan dosing in mice.

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Keywords: SN-38, NK012 supplier, Topoisomerase, inhibitors, activators


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