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SN-38 is an active metabolite of CPT-11, inhibits DNA topoisomerase I, DNA synthesis and causes frequent DNA single-strand breaks.
BMC Biol. 2021 May 20;19(1):108.
Very long intergenic non-coding (vlinc) RNAs directly regulate multiple genes in cis and trans
SN-38 purchased from AbMole
Nat Commun. 2019 Dec 20;10(1):5799.
Novel approach reveals genomic landscapes of single-strand DNA breaks with nucleotide resolution in human cells.
SN-38 purchased from AbMole
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Source | Customer experimental result (2018). |
| Method | Cell viability assay | |
| Cell Lines | MDA-MB-231 cells | |
| Concentrations | 32nM | |
| Incubation Time | 4 days | |
| Results | MDA-MB-231 cells were treated with 32nM SN-38 for 4 days and then incubated for 4 days. Most of the MDA-MB-231 cells were transformed into senescent cells. |
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Source | J Immunol Res (2018). Figure 1. SN-38 |
| Method | flow cytometry | |
| Cell Lines | NB cell lines | |
| Concentrations | 1 nM | |
| Incubation Time | 24 hours | |
| Results | Cisplatin at 2 μM, etoposide at 0.1 μM, irinotecan at 1 nM, and topotecan at 10nM induced apoptosis of all NB cell lines after 48 hours of treatment, with the exception of SK-N-AS treated with the first three drugs and SK-N-BE(2)c treated with all four drugs |
| Cell Experiment | |
|---|---|
| Cell lines | A-172, U-87, and LA-567 |
| Preparation method | MTT assay |
| Concentrations | 0 -1000 nM |
| Incubation time | 48 h |
| Animal Experiment | |
|---|---|
| Animal models | Nontumor-bearing mice |
| Formulation | dissolved in DMSO (1 mg/mL) |
| Dosages | 1 mg/kg |
| Administration | i.v. |
| Molecular Weight | 392.4 |
| Formula | C22H20N2O5 |
| CAS Number | 86639-52-3 |
| Solubility (25°C) | DMSO 21 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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|---|
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| 9-Hydroxyellipticine hydrochloride
9-Hydroxyellipticine hydrochloride is a inhibitor of Topo II and RyR. |
| Moxifloxacin-d4
Moxifloxacin-d4 |
| F14512
F14512 is a polyamine-containing inhibitor of DNA topoisomerase II with a broad spectrum of antitumor activities. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
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