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Ellagic acid is a natural antioxidant as well as a potent, ATP-competitive inhibitor of CK2 and SHP2 with IC50 and Ki values of 40 nM and 20 nM, respectively.In addition, Ellagic acid exhibits antiproliferative activity and inhibition of topoisomerase II (Topoisomerase II).
| Cell Experiment | |
|---|---|
| Cell lines | Peripheral blood mononuclear cells (PBMCs) |
| Preparation method | Cells were cultured in a humidified incubator maintained at 37 °C and 5% CO2 atmosphere with or without known concentrations of caffeic acid, ellagic acid and ferulic acid for 18 h. Cell viability was assayed by trypan exclusion method. |
| Concentrations | 100 and 200 μM |
| Incubation time | 18 h |
| Animal Experiment | |
|---|---|
| Animal models | Sprague-Dawley rat |
| Formulation | DMSO |
| Dosages | 75 mg/kg |
| Administration | IP injections |
| Molecular Weight | 302.19 |
| Formula | C14H6O8 |
| CAS Number | 476-66-4 |
| Solubility (25°C) | DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Jasmina Djedjibegovic, et al. Ellagic Acid-Derived Urolithins as Modulators of Oxidative Stress
[4] Giuseppe Derosa, et al. Ellagic Acid and Its Role in Chronic Diseases
| Related Topoisomerase Products |
|---|
| Amonafide
Amonafide is a unique ATP-independent Topo II inhibitor that is being studied in the treatment of cancer. |
| Camptothecin
Camptothecin (CPT), an alkaloid, is an inhibitor of DNA Topoisomerase I (Topo I) with an IC50 value of 679 nM. Camptothecin (CPT) has strong antitumor activity against colorectal cancer, breast cancer, lung cancer and ovarian cancer, and modulates hypoxia-inducible factor-1α (HIF-1α) activity by altering miRNA expression patterns in human cancer cells. |
| Pirarubicin
Pirarubicin is an anthracycline that is an inhibitor of Topoisomerase II.*The compound is unstable in solutions, freshly prepared is recommended |
| β-Lapachone
β-Lapachone is a selective DNA topoisomerase I inhibitor, exhibiting no inhibitory activities against DNA topoisomerase II or ligase. |
| Flumequine
Flumequine is a synthetic chemotherapeutic antibiotic, inhibiting topoisomerase II with IC50 of 15 μM. |
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