Pirarubicin is an anthracycline that is an inhibitor of Topoisomerase II. Pirarubicin showed inhibitory activity against M5076 and Ehrlich cells with IC50 of 0.366 and 0.078 μM, respectively. Pirarubicin (2.5,5,10 μg/mL) significantly induced autophagy in a dose-dependent manner in bladder cancer cells (T24, EJ, 5637, J82 and um-uc-3). Pirarubicin (5 μg/mL) induces apoptosis by inhibiting mTOR/p70S6K/4E-BP1 in bladder cancer cells and enhances this effect by inhibiting autophagy.
This compound is unstable in solutions for long time, freshly prepared is recommended.
*The compound is unstable in solutions, freshly prepared is recommended
ACS Biomater Sci Eng. 2021 Dec 21.
Strategies to Maximize Anthracycline Drug Loading in Albumin Microbubbles
Pirarubicin purchased from AbMole
| Molecular Weight | 627.64 |
| Formula | C32H37NO12 |
| CAS Number | 72496-41-4 |
| Solubility (25°C) | DMSO ≥ 10 mg/mL (Need ultrasonic) |
| Storage | 2-8°C, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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Topoisomerase II inhibitor 13 is a topoisomerase II (Topo II) inhibitor. |
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ICRF-196 is an racemic mixture of the (S,S)- and (R,R)-isomers of ICRF-193. |
| Cholesteryl hemisuccinate
Cholesteryl hemisuccinate is a with hepatoprotective an anticancer activity. |
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