All AbMole products are for research use only, cannot be used for human consumption.
Pirarubicin is an anthracycline that is an inhibitor of Topoisomerase II. Pirarubicin showed inhibitory activity against M5076 and Ehrlich cells with IC50 of 0.366 and 0.078 μM, respectively. Pirarubicin (2.5,5,10 μg/mL) significantly induced autophagy in a dose-dependent manner in bladder cancer cells (T24, EJ, 5637, J82 and um-uc-3). Pirarubicin (5 μg/mL) induces apoptosis by inhibiting mTOR/p70S6K/4E-BP1 in bladder cancer cells and enhances this effect by inhibiting autophagy.
This compound is unstable in solutions for long time, freshly prepared is recommended.
*The compound is unstable in solutions, freshly prepared is recommended
J Control Release. 2025 Feb 19;10:380:818-828.
Multidrug micelles and sonopermeation for chemotherapy co-delivery to brain tumors
Pirarubicin purchased from AbMole
ACS Biomater Sci Eng. 2021 Dec 21.
Strategies to Maximize Anthracycline Drug Loading in Albumin Microbubbles
Pirarubicin purchased from AbMole
| Molecular Weight | 627.64 |
| Formula | C32H37NO12 |
| CAS Number | 72496-41-4 |
| Solubility (25°C) | DMSO ≥ 10 mg/mL (Need ultrasonic) |
| Storage | 2-8°C, dry, sealed |
| Related Topoisomerase Products |
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| Amonafide
Amonafide is a unique ATP-independent Topo II inhibitor that is being studied in the treatment of cancer. |
| Camptothecin
Camptothecin (CPT), an alkaloid, is an inhibitor of DNA Topoisomerase I (Topo I) with an IC50 value of 679 nM. Camptothecin (CPT) has strong antitumor activity against colorectal cancer, breast cancer, lung cancer and ovarian cancer, and modulates hypoxia-inducible factor-1α (HIF-1α) activity by altering miRNA expression patterns in human cancer cells. |
| Ellagic acid
Ellagic acid is a natural antioxidant as well as a potent, ATP-competitive inhibitor of CK2 and SHP2 with IC50 and Ki values of 40 nM and 20 nM, respectively.In addition, Ellagic acid exhibits antiproliferative activity and inhibition of topoisomerase II (Topoisomerase II). |
| β-Lapachone
β-Lapachone is a selective DNA topoisomerase I inhibitor, exhibiting no inhibitory activities against DNA topoisomerase II or ligase. |
| Flumequine
Flumequine is a synthetic chemotherapeutic antibiotic, inhibiting topoisomerase II with IC50 of 15 μM. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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