All AbMole products are for research use only, cannot be used for human consumption.
Pirarubicin is an anthracycline that is an inhibitor of Topoisomerase II. Pirarubicin showed inhibitory activity against M5076 and Ehrlich cells with IC50 of 0.366 and 0.078 μM, respectively. Pirarubicin (2.5,5,10 μg/mL) significantly induced autophagy in a dose-dependent manner in bladder cancer cells (T24, EJ, 5637, J82 and um-uc-3). Pirarubicin (5 μg/mL) induces apoptosis by inhibiting mTOR/p70S6K/4E-BP1 in bladder cancer cells and enhances this effect by inhibiting autophagy.
This compound is unstable in solutions for long time, freshly prepared is recommended.
*The compound is unstable in solutions, freshly prepared is recommended
ACS Biomater Sci Eng. 2021 Dec 21.
Strategies to Maximize Anthracycline Drug Loading in Albumin Microbubbles
Pirarubicin purchased from AbMole
| Molecular Weight | 627.64 |
| Formula | C32H37NO12 |
| CAS Number | 72496-41-4 |
| Solubility (25°C) | DMSO ≥ 10 mg/mL (Need ultrasonic) |
| Storage | 2-8°C, dry, sealed |
| Related Topoisomerase Products |
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| XR11576
XR11576 (MLN576) is an orally active inhibitor of topoisomerase I and II. |
| Silatecan
Silatecan (AR-67; DB 67) is a Camptothecin analogue with improved stability and lipophilicity. |
| 9-Hydroxyellipticine hydrochloride
9-Hydroxyellipticine hydrochloride is a inhibitor of Topo II and RyR. |
| Moxifloxacin-d4
Moxifloxacin-d4 |
| F14512
F14512 is a polyamine-containing inhibitor of DNA topoisomerase II with a broad spectrum of antitumor activities. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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