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Camptothecin (CPT), an alkaloid, is an inhibitor of DNA Topoisomerase I (Topo I) with an IC50 value of 679 nM. Camptothecin (CPT) has strong antitumor activity against colorectal cancer, breast cancer, lung cancer and ovarian cancer, and modulates hypoxia-inducible factor-1α (HIF-1α) activity by altering miRNA expression patterns in human cancer cells.
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Camptothecin purchased from AbMole
| Molecular Weight | 348.36 |
| Formula | C20H16N2O4 |
| CAS Number | 7689-03-4 |
| Solubility (25°C) | DMSO 3 mg/mL |
| Storage | 2-8°C, protect from light |
[1] Liu LF, et al. Ann N Y Acad Sci. Mechanism of action of camptothecin.
| Related Topoisomerase Products |
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Silatecan (AR-67; DB 67) is a Camptothecin analogue with improved stability and lipophilicity. |
| 9-Hydroxyellipticine hydrochloride
9-Hydroxyellipticine hydrochloride is a inhibitor of Topo II and RyR. |
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Moxifloxacin-d4 |
| F14512
F14512 is a polyamine-containing inhibitor of DNA topoisomerase II with a broad spectrum of antitumor activities. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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