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Camptothecin

Cat. No. M2199
Camptothecin Structure
Synonym:

Camptothecine; (S)-(+)-Camptothecin; CPT

Size Price Availability Quantity
100mg USD 48  USD48 In stock
500mg USD 145  USD145 In stock
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Quality Control & Documentation
Biological Activity

Camptothecin (CPT), an alkaloid, is an inhibitor of DNA Topoisomerase I (Topo I) with an IC50 value of 679 nM. Camptothecin (CPT) has strong antitumor activity against colorectal cancer, breast cancer, lung cancer and ovarian cancer, and modulates hypoxia-inducible factor-1α (HIF-1α) activity by altering miRNA expression patterns in human cancer cells.

Chemical Information
Molecular Weight 348.36
Formula C20H16N2O4
CAS Number 7689-03-4
Solubility (25°C) DMSO 3 mg/mL
Storage 2-8°C, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Liu LF, et al. Ann N Y Acad Sci. Mechanism of action of camptothecin.

[2] Pantazis P, et al. Int J Cancer. Camptothecin derivatives induce regression of human ovarian carcinomas grown in nude mice and distinguish between non-tumorigenic and tumorigenic cells in vitro.

[3] Hsiang YH, et al. J Biol Chem. Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.

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Keywords: Camptothecin, Camptothecine; (S)-(+)-Camptothecin; CPT supplier, Topoisomerase, inhibitors, activators


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