About 11 results found for searched term "Camptothecin" (0.054 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M2199 | Camptothecin | Topoisomerase |
| Camptothecine; (S)-(+)-Camptothecin; CPT | ||
| Camptothecin (CPT), an alkaloid, is an inhibitor of DNA Topoisomerase I (Topo I) with an IC50 value of 679 nM. Camptothecin (CPT) has strong antitumor activity against colorectal cancer, breast cancer, lung cancer and ovarian cancer, and modulates hypoxia-inducible factor-1α (HIF-1α) activity by altering miRNA expression patterns in human cancer cells. | ||
| M4464 | 9-methoxycamptothecine | Others |
| 10-methoxycamptothecin, a natural bioactive derivative of camptothecin (CPT) isolated from Camptotheca acuminata, has been proven to have high anticancer properties. It was found that 10-methoxycamptothecin had higher cytotoxicity than 10-hydroxycamptothecin by measuring its antitumor activity against cell line 2774. | ||
| M7505 | 7-Ethylcamptothecin | Topoisomerase |
| 7-Ethyl Camptothecin is an anti-cancer chemical that exhibits a strong activity against various murine tumors through Topo I (topoisomerase) inhibition. | ||
| M7507 | 10-Hydroxycamptothecin | Topoisomerase |
| Hydroxy Camptothecine | ||
| 10-Hydroxycamptothecin is a cell-permeable powerful DNA topoisomerase I inhibitor. It has selective inhibitory effect on the phosphorylation of histone H1 and H3, but less effect on other histones. | ||
| M18370 | 9-Methoxycamptothecin | Others |
| 9-Methoxycamptothecin | ||
| M20401 | (S)-10-Hydroxycamptothecin | Topoisomerase |
| 10-HCPT | ||
| 10-Hydroxycamptothecin is a DNA topoisomerase I inhibitor with potent anti-tumor activity. | ||
| M20696 | Rubitecan | Topoisomerase |
| 9-NC, 9-Nitro-camptothecin, Partaject Orathecin, Partaject rubitecan, RFS 2000 | ||
| Rubitecan is a topoisomerase I inhibitor extracted from the bark and leaves of the Camptotheca acuminata tree, which is native to China. Rubitecan is an oral camptothecin with antitumour activity. | ||
| M25388 | 9-Aminocamptothecin | Topoisomerase |
| 9-amino-CPT; 9-amino-20(S)-camptothecin | ||
| 9-Aminocamptothecin (9-amino-CPT) is a topoisomerase I inhibitor with potent anticancer activity. 9-Aminocamptothecin inhibits PC-3, PC-3M, DU145, and LNCaP cells with IC50 values of 34.1, 10, 6.5, and 8.9 nM, respectively after 96 h exposure. | ||
| M28559 | (R)-FL118 | Others |
| 10,11-(Methylenedioxy)-20(R)-camptothecin | ||
| (R)-FL118 (10,11-(Methylenedioxy)-20(R)-camptothecin) is the R-enantiomer of FL118. (R)-FL118 shows anticancer activity. | ||
| M29040 | Camptothecin-20(S)-O-propionate | Topoisomerase |
| Camptothecin-20-O-propionate | ||
| Camptothecin-20(S)-O-propionate (CZ48), the C20-propionate ester of CPT, is a highly effective anticancer agent. Camptothecin-20(S)-O-propionate (CZ48) is a topoisomerase-Ι inhibitor. | ||
| M43107 | Camptothecin analog-1 | Others |
| Camptothecin analog-1 is a camptothecin analog. | ||
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