About 12 results found for searched term "Camptothecin" (0.067 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M2199 | Camptothecin | Topoisomerase |
| Camptothecine; (S)-(+)-Camptothecin; CPT | ||
| Camptothecin (CPT), an alkaloid, is an inhibitor of DNA Topoisomerase I (Topo I) with an IC50 value of 679 nM. Camptothecin (CPT) has strong antitumor activity against colorectal cancer, breast cancer, lung cancer and ovarian cancer, and modulates hypoxia-inducible factor-1α (HIF-1α) activity by altering miRNA expression patterns in human cancer cells. | ||
| M4464 | 9-methoxycamptothecine | Others |
| 10-methoxycamptothecin, a natural bioactive derivative of camptothecin (CPT) isolated from Camptotheca acuminata, has been proven to have high anticancer properties. It was found that 10-methoxycamptothecin had higher cytotoxicity than 10-hydroxycamptothecin by measuring its antitumor activity against cell line 2774. | ||
| M7505 | 7-Ethylcamptothecin | Topoisomerase |
| 7-Ethyl Camptothecin is an anti-cancer chemical that exhibits a strong activity against various murine tumors through Topo I (topoisomerase) inhibition. | ||
| M7507 | 10-Hydroxycamptothecin | Topoisomerase |
| Hydroxy Camptothecine | ||
| 10-Hydroxycamptothecin is a cell-permeable powerful DNA topoisomerase I inhibitor. It has selective inhibitory effect on the phosphorylation of histone H1 and H3, but less effect on other histones. | ||
| M18370 | 9-Methoxycamptothecin | Others |
| 9-Methoxycamptothecin | ||
| M20401 | (S)-10-Hydroxycamptothecin | Topoisomerase |
| 10-HCPT | ||
| 10-Hydroxycamptothecin is a DNA topoisomerase I inhibitor with potent anti-tumor activity. | ||
| M20696 | Rubitecan | Topoisomerase |
| 9-NC, 9-Nitro-camptothecin, Partaject Orathecin, Partaject rubitecan, RFS 2000 | ||
| Rubitecan is a topoisomerase I inhibitor extracted from the bark and leaves of the Camptotheca acuminata tree, which is native to China. Rubitecan is an oral camptothecin with antitumour activity. | ||
| M25388 | 9-Aminocamptothecin | Topoisomerase |
| 9-amino-CPT; 9-amino-20(S)-camptothecin | ||
| 9-Aminocamptothecin (9-amino-CPT) is a topoisomerase I inhibitor with potent anticancer activity. 9-Aminocamptothecin inhibits PC-3, PC-3M, DU145, and LNCaP cells with IC50 values of 34.1, 10, 6.5, and 8.9 nM, respectively after 96 h exposure. | ||
| M28559 | (R)-FL118 | Others |
| 10,11-(Methylenedioxy)-20(R)-camptothecin | ||
| (R)-FL118 (10,11-(Methylenedioxy)-20(R)-camptothecin) is the R-enantiomer of FL118. (R)-FL118 shows anticancer activity. | ||
| M29040 | Camptothecin-20(S)-O-propionate | Topoisomerase |
| Camptothecin-20-O-propionate | ||
| Camptothecin-20(S)-O-propionate (CZ48), the C20-propionate ester of CPT, is a highly effective anticancer agent. Camptothecin-20(S)-O-propionate (CZ48) is a topoisomerase-Ι inhibitor. | ||
| M43107 | Camptothecin analog-1 | Others |
| Camptothecin analog-1 is a camptothecin analog. | ||
| M58656 | O-acetylcamptothecin | Others |
| 20-O-Acetylcamptothecin; Camptothecin | ||
| O-acetylcamptothecin is a derivative of camptothecin, a naturally occurring alkaloid extracted from the bark of the Chinese tree Camptotheca acuminata. Camptothecin and its derivatives are primarily known for their potent anticancer properties, particularly through their action as inhibitors of topoisomerase I, an enzyme critical for DNA replication and transcription. | ||
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