Rubitecan is a topoisomerase I inhibitor extracted from the bark and leaves of the Camptotheca acuminata tree, which is native to China. Rubitecan is an oral camptothecin with antitumour activity.
|Solubility (25°C)||DMSO 58 mg/mL|
Powder -20°C 3 years ; 4°C 2 years
In solvent -80°C 6 months ; -20°C 1 month
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
 Jeffrey W Clark. Expert Opin Investig Drugs. Rubitecan
 No authors listed. Drugs R D. Rubitecan: 9-NC, 9-Nitro-20(S)-camptothecin, 9-nitro-camptothecin, 9-nitrocamptothecin, RFS 2000, RFS2000
 P M Fracasso, et al. Ann Oncol. Phase I study of rubitecan and gemcitabine in patients with advanced malignancies
 Howard Sands, et al. Anticancer Drugs. Preclinical activity of an i.v. formulation of rubitecan in IDD-P against human solid tumor xenografts
 Beppino C Giovanella, et al. Int J Oncol. Preclinical evaluation of the anticancer activity and toxicity of 9-nitro-20(S)-camptothecin (Rubitecan)
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