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(S)-10-Hydroxycamptothecin

Cat. No. M20401
(S)-10-Hydroxycamptothecin Structure
Synonym:

10-HCPT

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Biological Activity

10-Hydroxycamptothecin is a DNA topoisomerase I inhibitor with potent anti-tumor activity.

Chemical Information
Molecular Weight 364.35
Formula C20H16N2O5
CAS Number 19685-09-7
Solubility (25°C) DMSO 8 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Nasrin Aliabadi, et al. Heliyon. Evaluating the therapeutic efficacy of triptolide and (S)-10-hydroxycamptothecin on cutaneous and ocular Herpes Simplex Virus type-1 infections in mice

[2] Xing Liu, et al. Vet Microbiol. A natural product, (S)-10-Hydroxycamptothecin inhibits pseudorabies virus proliferation through DNA damage dependent antiviral innate immunity

[3] Hiroki Kurumi, et al. Cancers (Basel). Current Topics in Esophageal Squamous Cell Carcinoma

[4] Mengqiu Song, et al. Cancers (Basel). (S)-10-Hydroxycamptothecin Inhibits Esophageal Squamous Cell Carcinoma Growth In Vitro and In Vivo Via Decreasing Topoisomerase I Enzyme Activity

[5] Bing-Ying Xie, et al. Chin Med J (Engl). Organoid Culture of Isolated Cells from Patient-derived Tissues with Colorectal Cancer

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Keywords: (S)-10-Hydroxycamptothecin, 10-HCPT supplier, Topoisomerase, inhibitors, activators
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