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9-Aminocamptothecin (9-amino-CPT) is a topoisomerase I inhibitor with potent anticancer activity. 9-Aminocamptothecin inhibits PC-3, PC-3M, DU145, and LNCaP cells with IC50 values of 34.1, 10, 6.5, and 8.9 nM, respectively after 96 h exposure.
9-Aminocamptothecin (9-amino-CPT) inhibits tumor growth at the lowest oral dose (0.35 mg/kg/day), whereas higher oral doses (0.75 and 1 mg/kg/day) and s.c. administration (4 mg/kg/week) causes tumor regression. 9-Aminocamptothecin (9-amino-CPT) is well tolerated at all doses, with no toxic death or weight loss of more than 10% observed in any group. 9-Aminocamptothecin (9-amino-CPT) induces complete remissions in 55 % of SCID mice engrafted with human myeloid leukemia.
| Molecular Weight | 363.37 |
| Formula | C20H17N3O4 |
| CAS Number | 91421-43-1 |
| Solubility (25°C) | DMSO 3 mg/mL (Need ultrasonic) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] C H Takimoto, et al. Ann N Y Acad Sci. The clinical development of 9-aminocamptothecin
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