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Sodium Camptothecin is a reversible inhibitor of RNA synthesis. Sodium Camptothecin inhibits DNA synthesis and causes breaks in intracellular preformed viral DNA. Sodium Camptothecin is an effective inhibitor of adenovirus replication. Sodium Camptothecin is a plant alkaloid, with antitumor activity.
Sodium Camptothecin (5 μM; 10 min) causes a severe inhibition of heterogeneously sedimenting nuclear RNA (HnRNA) synthesis. Sodium Camptothecin also blocks a specific step in the processing of ribosomal precursor RNA, allowing the conversion of 45S RNA to 32S RNA, but inhibiting the conversion of 32S RNA to 28S RNA.
| Molecular Weight | 388.35 |
| Formula | C20H17N2NaO5 |
| CAS Number | 25387-67-1 |
| Solubility (25°C) | Water 40 mg/mL DMSO 20 mg/mL |
| Storage | 4°C, dry, sealed |
| Related DNA/RNA Synthesis Products |
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| Mizoribine
Mizoribine (Bredinin) is an imidazole nucleoside and an immunosuppressive agent with an IC50 of approximately 100 μM. Mizoribine inhibits replication of SARS-CoV with IC50s of 3.5 μg/mL and 16 μg/mL for SARS-CoV Frankfurt-1 and SARS-CoV HKU39849, respectively. |
| CDDP
Cisplatin is an inorganic platinum complex that inhibits DNA synthesis by forming DNA crosslinking agents, inactivates GPXs, reduces cell GSH and induces iron death in HCT116 and A549 cells. |
| Raltitrexed
Raltitrexed is an inhibitor of thymidylate synthase used in cancer chemotherapy. |
| Carmofur
Carmofur is a pyrimidine analog that is a prodrug of 5-fluorouracil (5-FU), which inhibits DNA Synthesis and has better antiproliferative activity than 5-FU. Carmofur is an inhibitor of Acidic Ceramidase (ASAH1) and a potential lead compound for non-cancer diseases such as Krabbe disease, acute lung injury (ALI), Parkinson's disease (PD), dementia, etc. Carmofur also has antifungal and antimicrobial properties. |
| 5-Fluorouracil
5-Fluorouracil (5-FU) is a potent antitumor agent that affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. |
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