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Irinotecan

Cat. No. M4465
Irinotecan Structure
Synonym:

(+)-Irinotecan; CPT-11

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mM*1mL in DMSO USD 60  USD60 In stock
50mg USD 65  USD65 In stock
100mg USD 97  USD97 In stock
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Quality Control
Biological Activity

Irinotecan is an inhibitor of Topoisomerase I, and is is activated by hydrolysis to SN-38 (the active metabolite of Irinotecan).

Product Citations
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 586.68
Formula C33H38N4O6
CAS Number 97682-44-5
Purity 99.58%
Solubility DMSO ≥ 20 mg/mL
Storage 2-8°C, protect from light, dry, sealed
References

[1] Filemon S Dela Cruz, et al. Genome Med. A case study of an integrative genomic and experimental therapeutic approach for rare tumors: identification of vulnerabilities in a pediatric poorly differentiated carcinoma

[2] Mei-Yun Huang, et al. Apoptosis. Chemotherapeutic agent CPT-11 eliminates peritoneal resident macrophages by inducing apoptosis

[3] C Morales, et al. J Neurooncol. Antitumoral effect of irinotecan (CPT-11) on an experimental model of malignant neuroectodermal tumor

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Irinotecan, (+)-Irinotecan; CPT-11 supplier, Topoisomerase, inhibitors

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