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Mitoxantrone dihydrochloride

Cat. No. M2217
Mitoxantrone dihydrochloride Structure
Synonym:

mitozantrone dihydrochloride

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
25mg USD 30  USD30 In stock
50mg USD 50  USD50 In stock
100mg USD 85  USD85 In stock
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Quality Control & Documentation
Biological Activity

Mitoxantrone dihydrochloride is a potent type II DNA topoisomerase inhibitor. Mitoxantrone dihydrochloride disrupts DNA synthesis and DNA repair in both healthy cells and cancer cells, by intercalation. Mitoxantrone dihydrochloride increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. Mitoxantrone dihydrochloride also displays broad immunosuppressive activity inhibiting proliferation of all classes of lymphocytes and inducing apoptosis of antigen-presenting T cells.

Chemical Information
Molecular Weight 517.4
Formula C22H28N4O6.2HCl
CAS Number 70476-82-3
Solubility (25°C) DMSO 40 mg/mL
Water 40 mg/mL
Storage 2-8°C, protect from light, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Scott LJ, et al. CNS Drugs. Mitoxantrone: a review of its use in multiple sclerosis.

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