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Gepotidacin

Cat. No. M25614

All AbMole products are for research use only, cannot be used for human consumption.

Gepotidacin Structure
Synonym:

GSK2140944

Size Price Availability Quantity
1mg USD 130  USD130 In stock
5mg USD 400  USD400 In stock
10mg USD 680  USD680 In stock
25mg USD 1350  USD1350 In stock
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Quality Control & Documentation
Biological Activity

Gepotidacin (GSK2140944) is a novel, potentially first-in-class, orally active triazaacenaphthylene antibiotic and type II topoisomerase (Topo II) inhibitor.Gepotidacin can selectively inhibit bacterial DNA replication by acting on DNA gyrase (GyrA) and topoisomerase IV (ParC).

Chemical Information
Molecular Weight 448.52
Formula C24H28N6O3
CAS Number 1075236-89-3
Form Solid
Solubility (25°C) DMSO 7.14 mg/mL
Storage -20°C
References

[1] Richard R Watkins, et al. J Antimicrob Chemother. Gepotidacin: a novel, oral, 'first-in-class' triazaacenaphthylene antibiotic for the treatment of uncomplicated urinary tract infections and urogenital gonorrhoea

[2] Charles Jakielaszek, et al. Sci Transl Med. Gepotidacin is efficacious in a nonhuman primate model of pneumonic plague

[3] Meredith A Hackel, et al. Antimicrob Agents Chemother. In Vitro Activity of Gepotidacin against Gram-Negative and Gram-Positive Anaerobes

[4] Mohammad Hossain, et al. Clin Pharmacol Drug Dev. Pharmacokinetics of Gepotidacin in Renal Impairment

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  Catalog
Abmole Inhibitor Catalog




Keywords: Gepotidacin, GSK2140944 supplier, Topoisomerase, inhibitors, activators

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