Free shipping on all orders over $ 500

Clinafloxacin

Cat. No. M2526
Clinafloxacin Structure
Synonym:

CI-960, PD127391, AM-1091

Size Price Availability Quantity
10mg USD 65  USD65 In stock
25mg USD 105  USD105 In stock
50mg USD 170  USD170 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Clinafloxacin is a fluoroquinolone that inhibits both DNA gyrase and topoisomerase IV dually in Streptococcus pneumoniae.

Chemical Information
Molecular Weight 365.79
Formula C17H17ClFN3O3
CAS Number 105956-97-6
Solubility (25°C) DMSO 1.8 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Michael T Sweeney, et al. Front Microbiol. In vitro activity and rodent efficacy of clinafloxacin for bovine and swine respiratory disease

Related Antibiotic Products
Kendomycin

Kendomycin is a polyketide antibiotic with significant antibacterial activity and tumor cytotoxicity. At low concentrations (MIC: 5 μg/mL), Kendomycin inhibits the growth of methicillin-resistant Staphylococcus aureus (MRSA) strain COL. In addition, Kendomycin is an endothelin receptor antagonist and calcitonin receptor agonist.

Ceftobiprole

Ceftobiprole is a broad-spectrum cephalosporin with rapid bactericidal activity against Gram-positive bacteria such as Staphylococcus aureus, including methicillin-resistant strains (MRSA), and Gram-negative bacteria, with a MIC90 value of 2 μg/mL against MRSA.

Showdomycin

Showdomycin is an antibiotic that is induced by IM-2 in Streptomyces.

Quinupristin

Quinupristin is a streptogramin antibiotic.

Buforin II

Buforin II, derived from buforin I, a protein isolated from the stomach of the Asian toad Bufo bufo gargarizans, is a potent antimicrobial peptide.

  Catalog
Abmole Inhibitor Catalog




Keywords: Clinafloxacin, CI-960, PD127391, AM-1091 supplier, Antibiotic, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.