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Amrubicin is a synthetic anthracycline which has been shown in preclinical studies to have broad-spectrum anti-tumor activity and a lower potential for cardiotoxicity as compared to doxorubicin. Amrubicin Shows Promise in Relapsed or Refractory Small Cell Lung Cancer.Amrubicin acts by inhibiting topoisomerase II, and has been compared in clinical trials with topotecan, a Topoisomerase I inhibitor.It has also been studied for the treatment of bladder carcinoma and gastric cancer. Amrubicin appears to have significant activity against invasive thymoma.
| Molecular Weight | 483.47 |
| Formula | C25H25NO9 |
| CAS Number | 110267-81-7 |
| Form | Solid |
| Solubility (25°C) | DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Topoisomerase Products |
|---|
| XR11576
XR11576 (MLN576) is an orally active inhibitor of topoisomerase I and II. |
| Silatecan
Silatecan (AR-67; DB 67) is a Camptothecin analogue with improved stability and lipophilicity. |
| 9-Hydroxyellipticine hydrochloride
9-Hydroxyellipticine hydrochloride is a inhibitor of Topo II and RyR. |
| Moxifloxacin-d4
Moxifloxacin-d4 |
| F14512
F14512 is a polyamine-containing inhibitor of DNA topoisomerase II with a broad spectrum of antitumor activities. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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