Free shipping on all orders over $ 500

Topoisomerase Topoisomerase

Cat.No.  Name Information
M2326 Etoposide (VP-16-213) Etoposide (VP-16-213) is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II inhibition activity.
M4465 Irinotecan Irinotecan is an inhibitor of Topoisomerase I, and is is activated by hydrolysis to SN-38 (the active metabolite of Irinotecan).
M3493 Mitoxantrone Mitoxantrone is a type II topoisomerase inhibitor with IC50 of 2.0 μM, 0.42 mM for HepG2 and MCF-7/wt cells, respectively
M2144 Topotecan hydrochloride Topotecan hydrochloride is a topoisomerase I inhibitor and an apoptosis inducer.
M3016 SN-38 SN-38 is an active metabolite of CPT-11, inhibits DNA topoisomerase I, DNA synthesis and causes frequent DNA single-strand breaks.
M2001 Idarubicin Idarubicin is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells.
M2265 Pirarubicin Pirarubicin is an anthracycline that is an inhibitor of Topoisomerase II.*The compound is unstable in solutions, freshly prepared is recommended
M3514 Moxifloxacin hydrochloride Moxifloxacin is a fourth-generation synthetic fluoroquinolone antibacterial agent.
M4903 Ciprofloxacin Ciprofloxacin is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity, with MIC90 of 0.024-6 μM.
M10708 Indotecan Indotecan (LMP-400) is a potent topoisomerase 1 (Top1) inhibitor. Indotecan (LMP-400) for P388, HCT116, MCF-7 cell linesIC50 The values are 300, 1200, 560 nM, respectively.
M10542 Alternariol Alternariol is a mycotoxin produced by Alternaria species. Alternariol inhibits the catalytic activity of topoisomerase I and topoisomerase II enzymes.
M10407 PNU-159682 PNU-159682 is a major active metabolite of nemorubicin (MMDX) in human liver microsomes, it is a highly potent DNA topoisomerase I inhibitor with excellent cytotoxicity. PNU-159682 is a potent ADCs cytotoxin.
M9695 Ellipticine hydrochloride Ellipticine (NSC 71795) hydrochloride is a potent antineoplastic agent which inhibits DNA topoisomerase II activities.
M9101 Exatecan mesylate Exatecan Mesylate is a water soluble topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL).
M9023 Ellipticine Ellipticine is a DNA intercalating agent and a DNA topoisomerase II inhibitor.
M8877 Pixantrone Maleate Pixantrone dimaleate is a topoisomerase II inhibitor and DNA intercalator, with anti-tumor activity.
M8683 Vosaroxin hydrochloride Vosaroxin hydrochloride is a novel quinolone derivative and first-in-class topoisomerase II inhibitor for AML-related studies.
M8640 SW044248 SW044248 is a cell permeable, indolotriazine-based compound that selectively inhibits topoisomerase 1 (Top 1), but not Top 2, catalyzed DNA decatenation in a manner distinct from that of camptothecin (Cat.
M7620 Amsacrine hydrochloride Amsacrine hydrochloride is a DNA topoisomerase II inhibitor.
M7507 10-Hydroxycamptothecin 10-Hydroxycamptothecin is a cell-permeable powerful DNA topoisomerase I inhibitor. It has selective inhibitory effect on the phosphorylation of histone H1 and H3, but less effect on other histones.
M7505 7-Ethylcamptothecin 7-Ethyl Camptothecin is an anti-cancer chemical that exhibits a strong activity against various murine tumors through Topo I (topoisomerase) inhibition.
M5882 Pirarubicin HCl Pirarubicin Hcl is an analogue of the anthracycline anti-neoplastic doxorubicin, which is an inhibitor of Topo II.
M5832 Ofloxacin Ofloxacin is a synthetic broad-spectrum antimicrobial agent.
M5825 Novobiocin Sodium Novobiocin Sodium is an aminocoumarin antibiotic that targets bacterial DNA gyrase (TopoIV), used to treat susceptible gram positive bacteria.
M5823 Norfloxacin Norfloxacin is a broad-spectrum antibiotic.
M5821 Nitroxoline Nitroxoline is a urinary antibacterial agent active against susceptible gram-positive and gram-negative organisms commonly found in urinary tract infections. It is a fluorquinolone that is active against bacterial gyrases.
M5737 Levofloxacin hydrate Levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. It acts by inhibiting DNA gyrase (bacterial topoisomerase II).
M5711 Irinotecan hydrochloride Irinotecan prevents DNA from unwinding by inhibition of topoisomerase 1.
M5617 Epirubicin HCl Epirubicin Hcl, a semisynthetic L-arabino derivative of doxorubicin, is an antineoplastic agent by inhibiting Topoisomerase. Epirubicin hydrochloride inhibits DNA and RNA synthesis. Epirubicin hydrochloride is a Forkhead box protein p3 (Foxp3) inhibitor and inhibits regulatory T cell activity.




Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.