| Cat.No. | Name | Information |
|---|---|---|
| M2326 | Etoposide (VP-16-213) | Etoposide (VP-16-213) is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II inhibition activity. |
| M4465 | Irinotecan | Irinotecan is an inhibitor of Topoisomerase I, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex. Irinotecan inhibits the growth of LoVo and HT-29 cells, with IC50s of 15.8 ± 5.1 and 5.17 ± 1.4 μM, respectively. |
| M3493 | Mitoxantrone | Mitoxantrone is a type II topoisomerase inhibitor with IC50 of 2.0 μM, 0.42 mM for HepG2 and MCF-7/wt cells, respectively |
| M2144 | Topotecan hydrochloride | Topotecan hydrochloride is a topoisomerase I inhibitor and an apoptosis inducer. |
| M3016 | SN-38 | SN-38 is an active metabolite of CPT-11, inhibits DNA topoisomerase I, DNA synthesis and causes frequent DNA single-strand breaks. |
| M2001 | Idarubicin | Idarubicin is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells. |
| M2265 | Pirarubicin | Pirarubicin is an anthracycline that is an inhibitor of Topoisomerase II.*The compound is unstable in solutions, freshly prepared is recommended |
| M3514 | Moxifloxacin hydrochloride | Moxifloxacin is a fourth-generation synthetic fluoroquinolone antibacterial agent. |
| M4903 | Ciprofloxacin | Ciprofloxacin is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity, with MIC90 of 0.024-6 μM. |
| M2199 | Camptothecin | Camptothecin (CPT), an alkaloid, is an inhibitor of DNA Topoisomerase I (Topo I) with an IC50 value of 679 nM. Camptothecin (CPT) has strong antitumor activity against colorectal cancer, breast cancer, lung cancer and ovarian cancer, and modulates hypoxia-inducible factor-1α (HIF-1α) activity by altering miRNA expression patterns in human cancer cells. |
| M13744 | Dxd | Dxd (Exatecan derivative for ADC) is a potent DNA topoisomerase I inhibitor, with an IC50 of 0.31 μM, used as a conjugated drug of HER2-targeting ADC (DS-8201a). |
| M13743 | Daun02 | Daun02 is a prodrug of the topoisomerase inhibitor Daunorubicin. |
| M13741 | Belotecan hydrochloride | Belotecan hydrochloride (CKD-602 hydrochloride), a Topoisomerase I inhibitor, is a synthetic camptothecin derivative. |
| M13740 | Amsacrine | Amsacrine (m-AMSA; acridinyl anisidide) is an inhibitor of topoisomerase II, and acts as an antineoplastic agent which can intercalates into the DNA of tumor cells. |
| M10993 | Berberine chloride hydrate | Berberine chloride hydrate (Natural Yellow 18 chloride hydrate) is an alkaloid commonly used as an antibiotic. Berberine chloride hydrate induces reactive oxygen species (ROS) production and inhibits DNA topoisomerase. Anti-tumor properties. |
| M10708 | Indotecan | Indotecan (LMP-400) is a potent topoisomerase 1 (Top1) inhibitor. Indotecan (LMP-400) for P388, HCT116, MCF-7 cell linesIC50 The values are 300, 1200, 560 nM, respectively. |
| M10542 | Alternariol | Alternariol is a mycotoxin produced by Alternaria species. Alternariol inhibits the catalytic activity of topoisomerase I and topoisomerase II enzymes. |
| M10407 | PNU-159682 | PNU-159682 is a major active metabolite of nemorubicin (MMDX) in human liver microsomes, it is a highly potent DNA topoisomerase I inhibitor with excellent cytotoxicity. PNU-159682 is a potent ADCs cytotoxin. |
| M9695 | Ellipticine hydrochloride | Ellipticine (NSC 71795) hydrochloride is a potent antineoplastic agent which inhibits DNA topoisomerase II activities. |
| M9101 | Exatecan mesylate | Exatecan Mesylate is a water soluble topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL). |
| M9023 | Ellipticine | Ellipticine is a DNA intercalating agent and a DNA topoisomerase II inhibitor. |
| M8877 | Pixantrone Maleate | Pixantrone dimaleate is a topoisomerase II inhibitor and DNA intercalator, with anti-tumor activity. |
| M8683 | Vosaroxin hydrochloride | Vosaroxin hydrochloride is a novel quinolone derivative and first-in-class topoisomerase II inhibitor for AML-related studies. |
| M8640 | SW044248 | SW044248 is a cell permeable, indolotriazine-based compound that selectively inhibits topoisomerase 1 (Top 1), but not Top 2, catalyzed DNA decatenation in a manner distinct from that of camptothecin (Cat. |
| M7640 | Bisantrene | Bisantrene is an antineoplastic agent, MDR1 substrate, DNA intercalator, and topoisomerase II poison. |
| M7620 | Amsacrine hydrochloride | Amsacrine hydrochloride is a DNA topoisomerase II inhibitor. Amsacrine hydrochloride acts as an antineoplastic agent which can intercalates into the DNA of tumor cells. |
| M7507 | 10-Hydroxycamptothecin | 10-Hydroxycamptothecin is a cell-permeable powerful DNA topoisomerase I inhibitor. It has selective inhibitory effect on the phosphorylation of histone H1 and H3, but less effect on other histones. |
| M7505 | 7-Ethylcamptothecin | 7-Ethyl Camptothecin is an anti-cancer chemical that exhibits a strong activity against various murine tumors through Topo I (topoisomerase) inhibition. |
| M5882 | Pirarubicin HCl | Pirarubicin Hcl is an analogue of the anthracycline anti-neoplastic doxorubicin, which is an inhibitor of Topo II. |
| M5825 | Novobiocin Sodium | Novobiocin Sodium is an aminocoumarin antibiotic that targets bacterial DNA gyrase (TopoIV), used to treat susceptible gram positive bacteria. |
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