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Topotecan (SKF 104864A; NSC 609669) is an orally active and potent Topoisomerase I inhibitor. Topotecan induces cell cycle arrest in G0/G1 and S phases and promotes apoptosis. Topotecan shows anticancer activity.
| Molecular Weight | 421.45 |
| Formula | C23H23N3O5 |
| CAS Number | 123948-87-8 |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] S Ackermann, et al. Int J Gynecol Cancer. Topotecan in cervical cancer
[5] D Ormrod, et al. Drugs. Topotecan: a review of its efficacy in small cell lung cancer
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