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Ellipticine (NSC71795) hydrochloride is a potent antineoplastic agent which inhibits DNA topoisomerase II activities. The mechanisms of Ellipticine (NSC71795) antitumor, mutagenic and cytotoxic activities are suggested to be intercalation into DNA and inhibition of DNA topoisomerase II activity. Another mode of Ellipticine (NSC71795) action is the formation of covalent DNA adducts mediated by its oxidation with cytochromes P450 (CYP) and peroxidases. The induced expression of cytochrome b5 protein in liver of rats treated with Ellipticine (NSC71795) suggests that cytochrome b5 may modulate the CYP-mediated bioactivation and detoxification of Ellipticine (NSC71795).
| Molecular Weight | 282.77 |
| Formula | C17H15ClN2 |
| CAS Number | 5081-48-1 |
| Solubility (25°C) | DMSO 10 mM |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Topoisomerase Products |
|---|
| XR11576
XR11576 (MLN576) is an orally active inhibitor of topoisomerase I and II. |
| Silatecan
Silatecan (AR-67; DB 67) is a Camptothecin analogue with improved stability and lipophilicity. |
| 9-Hydroxyellipticine hydrochloride
9-Hydroxyellipticine hydrochloride is a inhibitor of Topo II and RyR. |
| Moxifloxacin-d4
Moxifloxacin-d4 |
| F14512
F14512 is a polyamine-containing inhibitor of DNA topoisomerase II with a broad spectrum of antitumor activities. |
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