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Vosaroxin is an anti-cancer quinolone derivative that acts as a DNA intercalator and a topoisomerase II inhibitor, causing p53 independent tumor cell apoptosis. Vosaroxin stabilizes cleavage complexes formed by topoisomerase IIα and IIβ, which results in an accumulation of DNA double-strand breaks. Vosaroxin showed antineoplastic activity in multiple solid tumor and hematologic cancer cell lines and has been in clinical trials for AML.
| Molecular Weight | 437.9 |
| Formula | C18H19N5O4S · HCl |
| CAS Number | 175519-16-1 |
| Form | Solid |
| Solubility (25°C) | Water: 1 mg/mL (warmed) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Topoisomerase Products |
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| Amonafide
Amonafide is a unique ATP-independent Topo II inhibitor that is being studied in the treatment of cancer. |
| Camptothecin
Camptothecin (CPT), an alkaloid, is an inhibitor of DNA Topoisomerase I (Topo I) with an IC50 value of 679 nM. Camptothecin (CPT) has strong antitumor activity against colorectal cancer, breast cancer, lung cancer and ovarian cancer, and modulates hypoxia-inducible factor-1α (HIF-1α) activity by altering miRNA expression patterns in human cancer cells. |
| Ellagic acid
Ellagic acid is a natural antioxidant as well as a potent, ATP-competitive inhibitor of CK2 and SHP2 with IC50 and Ki values of 40 nM and 20 nM, respectively.In addition, Ellagic acid exhibits antiproliferative activity and inhibition of topoisomerase II (Topoisomerase II). |
| Pirarubicin
Pirarubicin is an anthracycline that is an inhibitor of Topoisomerase II.*The compound is unstable in solutions, freshly prepared is recommended |
| β-Lapachone
β-Lapachone is a selective DNA topoisomerase I inhibitor, exhibiting no inhibitory activities against DNA topoisomerase II or ligase. |
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