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Etoposide phosphate

Cat. No. M13745
Etoposide phosphate Structure


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Biological Activity

Etoposide phosphate (BMY-40481) is a potent anti-cancer chemotherapy agent and a selective topoisomerase II inhibitor to prevent re-ligation of DNA strands. Etoposide phosphate is the phosphate ester prodrug of etoposide and is considered as active equivalent to Etoposide. Etoposide phosphate induces cell cycle arrest, apoptosis, and autophagy.

Chemical Information
Molecular Weight 668.54
CAS Number 117091-64-2
Solubility (25°C) Water 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Winifred M Stockton, et al. J Oncol Pharm Pract. Etoposide and etoposide phosphate hypersensitivity in children: Incidence, risk factors, and prevention strategies

[2] Joel P Brooks, et al. J Oncol Pharm Pract. Etoposide phosphate for pediatric orthopedic malignancies after intravenous etoposide hypersensitivity

[3] K R Hande. Eur J Cancer. Etoposide: four decades of development of a topoisomerase II inhibitor

[4] L Schacter. Semin Oncol. Etoposide phosphate: what, why, where, and how?

[5] A H Witterland, et al. Pharm World Sci. Etoposide phosphate, the water soluble prodrug of etoposide

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Keywords: Etoposide phosphate, BMY-40481 supplier, Topoisomerase, inhibitors, activators

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