Etoposide phosphate (BMY-40481) is a potent anti-cancer chemotherapy agent and a selective topoisomerase II inhibitor to prevent re-ligation of DNA strands. Etoposide phosphate is the phosphate ester prodrug of etoposide and is considered as active equivalent to Etoposide. Etoposide phosphate induces cell cycle arrest, apoptosis, and autophagy.
|Solubility (25°C)||Water 90 mg/mL|
Powder -20°C 3 years ; 4°C 2 years
In solvent -80°C 6 months ; -20°C 1 month
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
 Winifred M Stockton, et al. J Oncol Pharm Pract. Etoposide and etoposide phosphate hypersensitivity in children: Incidence, risk factors, and prevention strategies
 Joel P Brooks, et al. J Oncol Pharm Pract. Etoposide phosphate for pediatric orthopedic malignancies after intravenous etoposide hypersensitivity
 K R Hande. Eur J Cancer. Etoposide: four decades of development of a topoisomerase II inhibitor
 L Schacter. Semin Oncol. Etoposide phosphate: what, why, where, and how?
 A H Witterland, et al. Pharm World Sci. Etoposide phosphate, the water soluble prodrug of etoposide
|Related Topoisomerase Products|
Rubitecan is a topoisomerase I inhibitor extracted from the bark and leaves of the Camptotheca acuminata tree, which is native to China. Rubitecan is an oral camptothecin with antitumour activity.
10-Hydroxycamptothecin is a DNA topoisomerase I inhibitor with potent anti-tumor activity.
WAY-272160 is a inhibitory activities for topoisomerase II and HER2
Gatifloxacin (AM-1155, CG5501, BMS-206584, PD135432) hydrochloride is a potent fluoroquinolone antibiotic with broad-spectrum antibacterial activity. Gatifloxacin hydrochloride inhibits bacterial type II topoisomerases with IC50 of 13.8 μg/ml and 0.109 μg/ml for S. aureus topoisomerase IV and E. coli DNA gyrase, respectively.
Aldoxorubicin (INNO-206) is an albumin-binding prodrug of Doxorubicin (DNA topoisomerase II inhibitor), which is released from albumin under acidic conditions.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.