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Cat. No. M4903
Ciprofloxacin Structure

Bay 09867

Size Price Availability Quantity
100mg USD 38  USD38 In stock
500mg USD 50  USD50 In stock
1g USD 66  USD66 In stock
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Quality Control & Documentation
Biological Activity

Ciprofloxacin inhibits topoisomerase IV as a primary topoisomerase target and gyrase as a secondary target. Ciprofloxacin (Bay-09867) (1 mg/L) induces glutathione-S-transferase (GST) activity, in contrast with inhibited GST and Catalase (CAT) of larvae exposed to enrofloxacin. Ciprofloxacin (Bay-09867) (≥10 μg/L) and enrofloxacin are ecotoxic for development, growth, detoxifying, and oxidative stress enzymes in anuran amphibian larvae.

Product Citations
Chemical Information
Molecular Weight 331.34
Formula C17H18FN3O3
CAS Number 85721-33-1
Solubility (25°C) Soluble in 0.1N HCl ~10mg/mL
Storage 2-8°C, protect from light, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Wise R, Antimicrob Agents Chemother. In vitro activity of Bay 09867, a new quinoline derivative, compared with those of other antimicrobial agents.

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Keywords: Ciprofloxacin, Bay 09867 supplier, Topoisomerase, inhibitors, activators

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