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Moxifloxacin is a fourth generation synthetic fluoroquinolone antibacterial agent. Moxifloxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria. It functions by inhibiting DNA gyrase, a type II topoisomerase and topoisomerase IV, which is an enzyme necessary to separate bacterial DNA, thereby inhibiting cell replication.
Queen Mary University of London. 2018 Feb.
Targeting APC loss using synthetic lethality in Colorectal Cancer
Moxifloxacin hydrochloride purchased from AbMole
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Source | Queen Mary University of London (2018 Feb). Figure 41. Moxifloxacin (Abmole Bioscience) |
| Method | Cell viability assay | |
| Cell Lines | APC wt 7_1 cell line | |
| Concentrations | 20, 40, 60, 80, 100 μM | |
| Incubation Time | 96 h | |
| Results | we hypothesised that the drugs may have degraded over the course of the repeats; losartan potassium, moxifloxacin hydrochloride, saxagliptin, mesalamine and desonide |
| Molecular Weight | 437.89 |
| Formula | C21H24FN3O4.HCl |
| CAS Number | 186826-86-8 |
| Solubility (25°C) | DMSO 80 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Hung-Jen Tang, et al. Lefamulin vs moxifloxacin for community-acquired bacterial pneumonia
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