| Cat.No. | Name | Information |
|---|---|---|
| M2326 | Etoposide (VP-16-213) | Etoposide (VP-16-213) is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II inhibition activity. |
| M4465 | Irinotecan | Irinotecan is an inhibitor of Topoisomerase I, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex. Irinotecan inhibits the growth of LoVo and HT-29 cells, with IC50s of 15.8 ± 5.1 and 5.17 ± 1.4 μM, respectively. |
| M3493 | Mitoxantrone | Mitoxantrone is a type II topoisomerase inhibitor with IC50 of 2.0 μM, 0.42 mM for HepG2 and MCF-7/wt cells, respectively |
| M2144 | Topotecan hydrochloride | Topotecan hydrochloride is a topoisomerase I inhibitor and an apoptosis inducer. |
| M3016 | SN-38 | SN-38 is an active metabolite of CPT-11, inhibits DNA topoisomerase I, DNA synthesis and causes frequent DNA single-strand breaks. |
| M2001 | Idarubicin | Idarubicin is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells. |
| M2265 | Pirarubicin | Pirarubicin is an anthracycline that is an inhibitor of Topoisomerase II.*The compound is unstable in solutions, freshly prepared is recommended |
| M3514 | Moxifloxacin hydrochloride | Moxifloxacin is a fourth-generation synthetic fluoroquinolone antibacterial agent. |
| M4903 | Ciprofloxacin | Ciprofloxacin is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity, with MIC90 of 0.024-6 μM. |
| M2199 | Camptothecin | Camptothecin (CPT), an alkaloid, is an inhibitor of DNA Topoisomerase I (Topo I) with an IC50 value of 679 nM. Camptothecin (CPT) has strong antitumor activity against colorectal cancer, breast cancer, lung cancer and ovarian cancer, and modulates hypoxia-inducible factor-1α (HIF-1α) activity by altering miRNA expression patterns in human cancer cells. |
| M5823 | Norfloxacin | Norfloxacin is a broad-spectrum antibiotic. Norfloxacin (MK-0366) is active against both Gram-positive and Gram-negative bacteria, which functions by inhibiting DNA gyrase. |
| M5737 | Levofloxacin hydrate | Levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. It acts by inhibiting DNA gyrase (bacterial topoisomerase II). |
| M5711 | Irinotecan hydrochloride | Irinotecan hydrochloride ((+)-Irinotecan hydrochloride) is a topoisomerase I inhibitor. Irinotecan prevents DNA from unwinding by inhibition of topoisomerase 1. |
| M5617 | Epirubicin hydrochloride | Epirubicin hydrochloride, a semisynthetic L-arabino derivative of doxorubicin, is an antineoplastic agent by inhibiting Topoisomerase. Epirubicin hydrochloride inhibits DNA and RNA synthesis. Epirubicin hydrochloride is a Forkhead box protein p3 (Foxp3) inhibitor and inhibits regulatory T cell activity. |
| M5443 | Balofloxacin | Balofloxacin is a quinolone antibiotic, inhibiting the synthesis of bacterial DNA by interference with the enqyme DNA gyrase. |
| M4860 | Idarubicin HCl | Idarubicin HCl is a hydrochloride salt form of Idarubicin which is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells with IC50 of 3.3 ng/mL in a cell-free assay. |
| M4403 | Groenlandicine | Groenlandicine is a proto berberine alkaloid isolated from coptis chinensis. Groenlandicine has moderate inhibition of human recombinant aldose reductase (HRAR) with an IC50 value of 154.2 μM. Groenlandicine induces DNA cleavage mediated by topoisomerase I. |
| M3989 | Vosaroxin | Vosaroxin is a novel first-in-class quinolone derivative that has been developed for use in the treatment of AML as a new-generation topo II inhibitor. |
| M3784 | Genz-644282 | Genz 644282 is a novel non-camptothecin topoisomerase I inhibitor with an IC50 value of 0.4 nM in human bone marrow CFU-GM assay. |
| M3725 | TAS-103 dihydrochloride | TAS-103, also known as BMS-247615, is a quinoline derivative that displays antitumor activity in murine and human tumor models. |
| M3720 | Moxifloxacin | Moxifloxacin is an extended-spectrum fluoroquinolone which has improved coverage against gram-positive cocci and atypical pathogens compared with older fluoroquinolone agents, while retaining good activity against gram-negative bacteria. |
| M3697 | Amrubicin | Amrubicin is a third-generation anthracycline and potent topoisomerase II inhibitor, showed promising activity in small-cell lung cancer (SCLC) in phase II trials. |
| M3313 | Teniposide | Teniposide is a chemotherapeutic medication mainly used in the treatment of childhood acute lymphocytic leukemia (ALL). |
| M2918 | Pefloxacin Mesylate Dihydrate | Pefloxacin Mesylate Dihydrate is the third generation of fluoroquinolone class of antibacterials, which inhibits Topoisomerase II activity and DNA replication. |
| M2707 | Flumequine | Flumequine is a synthetic chemotherapeutic antibiotic, inhibiting topoisomerase II with IC50 of 15 μM. |
| M2453 | β-Lapachone | β-Lapachone is a selective DNA topoisomerase I inhibitor, exhibiting no inhibitory activities against DNA topoisomerase II or ligase. |
| M2252 | Ellagic acid | Ellagic acid is a natural antioxidant as well as a potent, ATP-competitive inhibitor of CK2 and SHP2 with IC50 and Ki values of 40 nM and 20 nM, respectively.In addition, Ellagic acid exhibits antiproliferative activity and inhibition of topoisomerase II (Topoisomerase II). |
| M2217 | Mitoxantrone dihydrochloride | Mitoxantrone dihydrochloride is a potent topoisomerase II inhibitor. Mitoxantrone dihydrochloride also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM. |
| M2089 | Irinotecan Hydrochloride Trihydrate | Irinotecan hydrochloride trihydrate is a potent inhibitor of DNA topoisomerase I. |
| M2057 | Dexrazoxane hydrochloride | Dexrazoxane HCl (ICRF-187, ADR-529, DXZ) is an iron chelator that can be used to prevent DOX-induced cardiotoxicity. |
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