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TAS-103 has been reported to be a potent topoisomerase II poison. TAS-103 showed the strongest antitumor activity among the conventional anticancer agents for colorectal cancer (p<0.05). The combination with CDDP augmented the antitumor activity of TAS-103 (p<0.05), indicating that CDDP is one of the most potent candidates to be used in combination with TAS-103. TAS-103 may be useful in the chemotherapy of colorectal cancer. TAS-103 is a novel type of anticancer agent with a unique mechanism and could be useful as a lead compound for development of new drugs.TAS-103 will be expected to show excellent antitumor activities against a wide range of human tumors. TAS-103 showed the strongest antitumor activity among the conventional anticancer agents for colorectal cancer (p<0.05).
| Molecular Weight | 406.31 |
| Formula | C20H21Cl2N3O2 |
| CAS Number | 174634-09-4 |
| Solubility (25°C) | Water 40 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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