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Teniposide

Cat. No. M3313
Teniposide Structure
Synonym:

VM26

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mM*1mL in DMSO USD 60  USD60 In stock
25mg USD 56  USD56 In stock
50mg USD 98  USD98 In stock
100mg USD 142  USD142 In stock
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Quality Control & Documentation
Biological Activity

Teniposide (Vumon) is a chemotherapeutic medication mainly used in the treatment of childhood acute lymphocytic leukemia (ALL). It is in a class of drugs known as podophyllotoxin derivatives and slows the growth of cancer cells in the body. Teniposide causes dose-dependent single- and double-stranded breaks in DNA and DNA-protein cross-links. The mechanism of action appears to be related to the inhibition of type II topoisomerase activity since teniposide does not intercalate into DNA or bind strongly to DNA.

Chemical Information
Molecular Weight 656.65
Formula C32H32O13S
CAS Number 29767-20-2
Solubility (25°C) DMSO 30 mg/mL
Storage -20°C, protect from light, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] F M Muggia. Teniposide: overview of its therapeutic potential in adult cancers

[2] P I Clark, et al. The clinical pharmacology of etoposide and teniposide

[3] J L Grem, et al. Teniposide in the treatment of leukemia: a case study of conflicting priorities in the development of drugs for fatal diseases

[4] M Bjrkholm. Etoposide and teniposide in the treatment of acute leukemia

[5] J G McVie. Teniposide (VM-26) in brain tumors

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Keywords: Teniposide, VM26 supplier, Topoisomerase, inhibitors, activators


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