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Recombinant Human VEGF165（HEK293） is a powerful growth and angiogenic cytokine. It promotes the proliferation and survival of endothelial cells, promotes angiogenesis and vascular permeability. VEGF is expressed in vascularized tissues and plays an important role in normal and pathological angiogenesis.
Sci Rep. 2019 Nov 28;9(1):17745.
In vivo delivery of VEGF RNA and protein to increase osteogenesis and intraosseous angiogenesis
Recombinant Human VEGF165（HEK293） purchased from AbMole
| Solubility (25°C) | Water Saline PBS |
| Storage | 2-8°C, dry, protect from light, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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