IWP-L6 is a highly potent Porcn inhibitor with EC50 of 0.5 nM.
Nucleic Acids Res. 2024 Feb;gkae057.
Selection-free precise gene repair using high-capacity adenovector delivery of advanced prime editing systems rescues dystrophin synthesis in DMD muscle cells
IWP-L6 purchased from AbMole
Nucleic Acids Res. 2022 Jul 22;50(13):7761-7782.
Large-scale genome editing based on high-capacity adenovectors and CRISPR-Cas9 nucleases rescues full-length dystrophin synthesis in DMD muscle cells
IWP-L6 purchased from AbMole
Cell Reports Methods. 2022 Oct 24.
STRAIGHT-IN enables high-throughput targeting of large DNA payloads in human pluripotent stem cells
IWP-L6 purchased from AbMole
Stem Cell Res. 2020 Mar;43:101698.
Cryopreservation of human pluripotent stem cell-derived cardiomyocytes is not detrimental to their molecular and functional properties.
IWP-L6 purchased from AbMole
Molecular Weight | 472.58 |
Formula | C25H20N4O2S2 |
CAS Number | 1427782-89-5 |
Solubility (25°C) | DMSO ≥ 15 mg/mL (with 50ºC water bath) |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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