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IWP-L6

Cat. No. M2781
IWP-L6 Structure
Synonym:

Porcn Inhibitor III

Size Price Availability Quantity
10mg USD 97.2  USD108 In stock
50mg USD 310.5  USD345 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
Biological Activity

IWP-L6 is a highly potent Porcn inhibitor with EC50 of 0.5 nM.

Product Citations
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 472.58
Formula C25H20N4O2S2
CAS Number 1427782-89-5
Purity 99.89%
Solubility DMSO ≥ 15 mg/mL (with 50ºC water bath)
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: IWP-L6, Porcn Inhibitor III supplier, Wnt/beta-catenin, inhibitors

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