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IWP-L6

Cat. No. M2781
IWP-L6 Structure
Synonym:

Porcn Inhibitor III

Size Price Availability Quantity
10mg USD 80  USD80 In stock
50mg USD 280  USD280 In stock
100mg USD 500  USD500 In stock
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Quality Control
Biological Activity

IWP-L6 is a highly potent Porcn inhibitor with EC50 of 0.5 nM.

Product Citations
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 472.58
Formula C25H20N4O2S2
CAS Number 1427782-89-5
Purity 99.89%
Solubility DMSO ≥ 15 mg/mL (with 50ºC water bath)
Storage at -20°C
References

[1] Jia Yu, et al. Structural model of human PORCN illuminates disease-associated variants and drug-binding sites

[2] Ximena Volpini, et al. Wnt Signaling Plays a Key Role in the Regulation of the Immune Response and Cardiac Damage during Trypanosoma cruzi Infection

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Keywords: IWP-L6, Porcn Inhibitor III supplier, Wnt/beta-catenin, inhibitors

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