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Wnt/beta-catenin Wnt/beta-catenin

Cat.No.  Name Information
M2008 ICG-001 ICG-001 is a novel small molecule inhibitor of TCF/beta-catenin-mediated transcription.
M1796 XAV939 XAV939 is a potent, cell-permeable small molecule inhibitor of the Wnt/β-catenin pathway to TNKS1 and TNKS2 with IC50 values of 11 and 4 nM respectively.
M2781 IWP-L6 IWP-L6 is a highly potent Porcn inhibitor with EC50 of 0.5 nM.
M2237 IWP-2 IWP-2 is an inhibitor of Wnt production that impairs Wnt pathway activity in vitro with an IC50 value of 27 nM.
M2782 IWR-1-endo IWR-1 (endo-IWR 1) is a Wnt pathway inhibitor with IC50 of 180 nM, induces Axin2 protein levels and promotes β-catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes.
M24733 Tabituximab barzuxetan Tabituximab barzuxetan (OTSA101-DTPA-90Y) is a radioimmunoconjugate composed of a humanized monoclonal antibody targeting FZD-10 (OTSA-101), and labeled with Yttrium 90. Tabituximab barzuxetan shows antineoplastic activity. Tabituximab barzuxetan can be used for synovial sarcoma research.
M24643 Ipafricept Ipafricept (OMP-54F28; FZD8-Fc) is the first class of recombinant fusion proteins, consisting of the extracellular portion of the human fried-8 receptor fused to the Fc fragment of human IgG1 binding to the Wnt ligand. Ipafricept shows solid tumor inhibition activity, with well tolerance.
M20629 IWP-O1 IWP-O1 is a porcn inhibitor with an EC50 value of 80 pM in a cultured cell reporter assay of Wnt signaling and effectively suppresses the phosphorylation of Dvl2/3 in HeLa cells.
M14941 Tegatrabetan Tegatrabetan (BC2059) is a β-Catenin antagonist. Tegatrabetan disrupts the binding of β-catenin with the scaffold protein transducin β-like 1 (TBL1).
M14940 CWP232228 CWP232228, a highly potent selective Wnt/β-catenin signaling inhibitor, antagonizes binding of β-catenin to T-cell factor (TCF) in the nucleus.
M14939 β-catenin-IN-2 β-catenin-IN-2 is a potent β-catenin inhibitor, compound H1B1, extracted from patent US20150374662A1. β-catenin-IN-2 can be used for the study of colorectal cancer.
M14935 YB-0158 YB-0158 (Wnt pathway inhibitor 2) is a reverse-turn peptidomimetic and a potent colorectal cancer stem cell (CSC) targeting agent. YB-0158 disrupts Sam68-Src interactions and induces apoptosis in CRC cells. Anti-cancer activities.
M14934 Pyrvinium pamoate Pyrvinium pamoate is an FDA-approved antihelmintic drug that inhibits WNT pathway signaling.
M14933 KY1220 KY1220 is a compound that destabilizes both β-catenin and Ras, via targeting the Wnt/β-catenin pathway; with an IC50 of 2.1 μM in HEK293 reporter cells.
M14932 HLY78 HLY78 is an activator of the Wnt/β-catenin signaling pathway, which targets the DIX domain of Axin and potentiates the Axin-LRP6 association to promote Wnt signaling transduction.
M14931 Gigantol Gigantol is a bibenzyl compound derived from several medicinal orchids. Giganto shows promising therapeutic potential against cancer cells. Gigantol is a novel inhibitor of the Wnt/β-catenin pathway.
M11484 Cinobufotalin Cinobufotalin is a cardiotonic steroid, or butadienolide, derived from the skin secretions of toads. SREBP1 is a novel inhibitor that inhibits the proliferation of hepatocellular carcinoma by targeting adipogenesis.
M11012 NLS-StAx-h NLS-StAx-h is a selective fixed peptide inhibitor of Wnt signaling,IC50 1.4 μM.
M10996 Methyl vanillate Methyl vanillate, an extract found in the genus Loquat, is a Wnt/β-catenin signaling pathway activator. Benzoate, is the methyl ester of vanillin. It has antioxidant effects. Plant metabolites.
M10710 L-Quebrachitol L-Quebrachitol is a natural product isolated from a variety of plants that promotes osteoblast production by upregulating BMP-2, runt-associated transcription factor (Runx2), MAPK (ERK, JNK, p38α), and Wnt/β-catenin signaling pathways.
M10678 PRI-724 PRI-724 (C-82 prodrug, ICG-001 analog) is a potent, specific inhibitor that disrupts the interaction of β-catenin and CBP
M10577 Foxy-5 TFA As an agonist of WNT5A, FOxy-5 is a formylated WNT5A-mimicking peptide that triggers cytoplasmic free calcium signaling without affecting β-catenin activation and impels epithelial cancer cell migration and invasion.
M10056 FIDAS-5 FIDAS-5 is a potent and orally active methionine S-adenosyltransferase 2A (MAT2A) inhibitor with an IC50 of 2.1 μM.
M9790 BML-284 BML-284 (Wnt agonist 1) is a potent and selective activator of Wnt signaling.
M9760 Chicken egg albumin Chicken egg albumin, or ovalbumin, is the major protein constituent of egg whites. Chicken egg albumin is a phosphorylated glycoprotein.

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