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Wnt/beta-catenin Wnt/beta-catenin

Inhibitors

Cat.No.  Name Information
M2008 ICG-001 ICG-001 is a novel small molecule inhibitor of TCF/beta-catenin-mediated transcription.
M1796 XAV939 XAV939 is a potent, cell-permeable small molecule inhibitor of the Wnt/β-catenin pathway to TNKS1 and TNKS2 with IC50 values of 11 and 4 nM respectively.
M2781 IWP-L6 IWP-L6 is a highly potent Porcn inhibitor with EC50 of 0.5 nM.
M2237 IWP-2 IWP-2 is an inhibitor of Wnt production that impairs Wnt pathway activity in vitro with an IC50 value of 27 nM.
M11012 NLS-StAx-h NLS-StAx-h is a selective fixed peptide inhibitor of Wnt signaling,IC50 1.4 μM.
M10996 Methyl vanillate Methyl vanillate, an extract found in the genus Loquat, is a Wnt/β-catenin signaling pathway activator. Benzoate, is the methyl ester of vanillin. It has antioxidant effects. Plant metabolites.
M10710 L-Quebrachitol L-Quebrachitol is a natural product isolated from a variety of plants that promotes osteoblast production by upregulating BMP-2, runt-associated transcription factor (Runx2), MAPK (ERK, JNK, p38α), and Wnt/β-catenin signaling pathways.
M10678 PRI-724 PRI-724 (C-82 prodrug, ICG-001 analog) is a potent, specific inhibitor that disrupts the interaction of β-catenin and CBP
M10577 Foxy-5 TFA Foxy-5 TFA, a WNT5A agonist, is a mimicking peptide of WNT5A which is a non-canonical member of the Wnt family. Foxy-5 TFA triggers cytosolic free calcium signaling without affecting β-catenin activation and it impairs the migration and invasion of epithelial cancer cells.
M10056 FIDAS-5 FIDAS-5 is a potent and orally active methionine S-adenosyltransferase 2A (MAT2A) inhibitor with an IC50 of 2.1 μM.
M9790 BML-284 BML-284 (Wnt agonist 1) is a potent and selective activator of Wnt signaling.
M9478 SKL2001 SKL2001 is a novel agonist of Wnt/β-catenin pathway with anti-cancer activity.
M9424 Adavivint Adavivint (SM04690) is a potent and specific inhibitor of canonical Wnt signaling with an EC50 of 19.5 nM for inhibiting the TCF/LEF reporter.
M9417 Gallocyanine Gallocyanine is a small molecule DKK1 inhibitor, which blocks DKK1 inhibitory activity on Wnt signaling.
M9168 Berberine Berberine is an alkaloid in several plants with various biological functions, including insulin-sensitizing, anti-inflammatory, and anti-oxidant activity.
M8934 ETC-159 ETC-159 is a potent, selective and orally available PORCN inhibitor, which inhibits β-catenin reporter activity with an IC50 of 2.9 nM.
M8173 Salinomycin Salinomycin is a carboxylic polyether ionophore with antibiotic and anti-cancer properties.
M6855 JW 74 JW 74 is a wnt pathway inhibitor, with an IC50 of 420 nM.
M5279 NCB-0846 NCB-0846 is a novel, orally small-molecule Wnt inhibitor that inhibits TNIK (TRAF2 and NCK-Interacting Kinase) with an IC50 value of 21 nM.
M5261 CP21R7 CP21R7, also known CP21, is a potent and selective GSK-3β inhibitor that can potently activate canonical Wnt signalling.
M4866 LF3 LF3 is a specific inhibitor of canonical Wnt signaling by disrupting the interaction between β-catenin and TCF4 with an IC50 less than 2 μM.
M4829 WIKI4 WIKI4 is a potent inhibitor of Wnt/β-catenin signaling (EC50 ~ 75 nM) that inhibits auto-ADP-ribosylation of tankyrase 2 (TNKS2) (IC50 ~15 nM).
M4632 Xanthatin Xanthatin has antibacterial and antifungal activies against MRSA.
M4452 Echinacoside Echinacoside is a phenylethanol compound isolated from Cistanche salsa that effectively inhibits the Wnt/β-catenin signaling pathway. Echinacoside plays a neuroprotective role by activating Trk receptors and their downstream signaling pathways. Echinacoside also has significant anti-osteoporosis activity.



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