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IWR-1-endo

Cat. No. M2782
IWR-1-endo Structure
Synonym:

endo-IWR 1; IWR-1

Size Price Availability Quantity
5mg USD 46.8  USD52 In stock
10mg USD 81  USD90 In stock
25mg USD 184.5  USD205 In stock
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Quality Control
Biological Activity

IWR-1 (endo-IWR 1) is a Wnt pathway inhibitor with IC50 of 180 nM, induces Axin2 protein levels and promotes β-catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes.

Customer Product Validations & Biological Datas
Source Sci Rep (2017). Figure 3. IWR-1-endo
Method qPCR
Cell Lines EMSC osteogenic
Concentrations 10 μM
Incubation Time 24 h
Results To further study whether the Wnt/β-catenin pathway is involved in regulating EMSC osteogenic differentiation, we treated EMSCs with the Wnt signalling inhibitor IWR-1-endo and the Wnt signalling agonist SKL2001 before osteogenic induction.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 409.44
Formula C25H19N3O3
CAS Number 1127442-82-3
Purity 100.00%
Solubility DMSO 30 mg/mL
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: IWR-1-endo, endo-IWR 1; IWR-1 supplier, Wnt/beta-catenin, inhibitors

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