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Cat. No. M2782
IWR-1-endo Structure

endo-IWR 1; IWR-1

Size Price Availability Quantity
5mg USD 50  USD50 In stock
10mg USD 85  USD85 In stock
25mg USD 188  USD188 In stock
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Quality Control
Biological Activity

IWR-1 (endo-IWR 1) is a Wnt pathway inhibitor with IC50 of 180 nM, induces Axin2 protein levels and promotes β-catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes.

Customer Product Validations & Biological Datas
Source Sci Rep (2017). Figure 3. IWR-1-endo
Method qPCR
Cell Lines EMSC osteogenic
Concentrations 10 μM
Incubation Time 24 h
Results To further study whether the Wnt/β-catenin pathway is involved in regulating EMSC osteogenic differentiation, we treated EMSCs with the Wnt signalling inhibitor IWR-1-endo and the Wnt signalling agonist SKL2001 before osteogenic induction.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 409.44
Formula C25H19N3O3
CAS Number 1127442-82-3
Purity 100.00%
Solubility DMSO 30 mg/mL
Storage at -20°C

[1] Jia Sun, et al. aFGF alleviates diabetic endothelial dysfunction by decreasing oxidative stress via Wnt/β-catenin-mediated upregulation of HXK2

[2] Wei Wang, et al. IWR-1 Inhibits Collagen-Induced Platelet Activation and Protects against Thrombogenesis

[3] Carl T Gustafson, et al. Efflux inhibition by IWR-1-endo confers sensitivity to doxorubicin effects in osteosarcoma cells

[4] Ming-Wei Zhou, et al. Inhibition of collagen synthesis by IWR-1 in normal and keloid-derived skin fibroblasts

[5] Sang Chul Lee, et al. IWR-1 inhibits epithelial-mesenchymal transition of colorectal cancer cells through suppressing Wnt/β-catenin signaling as well as survivin expression

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Keywords: IWR-1-endo, endo-IWR 1; IWR-1 supplier, Wnt/beta-catenin, inhibitors

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