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IWR-1 (endo-IWR 1) is a Wnt pathway inhibitor with IC50 of 180 nM, induces Axin2 protein levels and promotes β-catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes.
Aquaculture Reports. 2023 Dec;101784.
Squalene activates Wnt/β-Catenin signaling pathway to mediate NF-κB pathway to regulate inflammatory response and disease resistance in hybrid grouper
IWR-1-endo purchased from AbMole
Adv Sci (Weinh). 2022 Nov 14;10(1):e2205451.
Podocalyxin‐Like Protein 1 Regulates Pluripotency through the Cholesterol Biosynthesis Pathway
IWR-1-endo purchased from AbMole
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Source | Sci Rep (2017). Figure 3. IWR-1-endo |
| Method | qPCR | |
| Cell Lines | EMSC osteogenic | |
| Concentrations | 10 μM | |
| Incubation Time | 24 h | |
| Results | To further study whether the Wnt/β-catenin pathway is involved in regulating EMSC osteogenic differentiation, we treated EMSCs with the Wnt signalling inhibitor IWR-1-endo and the Wnt signalling agonist SKL2001 before osteogenic induction. |
| Molecular Weight | 409.44 |
| Formula | C25H19N3O3 |
| CAS Number | 1127442-82-3 |
| Solubility (25°C) | DMSO 30 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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| UU-T02
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| Calphostin C
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