| Cat.No. | Name | Information |
|---|---|---|
| M2008 | ICG-001 | ICG-001 is a novel small molecule inhibitor of TCF/beta-catenin-mediated transcription. ICG-001 specifically binds to cyclic AMP response element-binding protein with an IC50 of 3 μM. |
| M1796 | XAV939 | XAV939 is a potent, cell-permeable small molecule inhibitor of the Wnt/β-catenin pathway to TNKS1 and TNKS2 with IC50 values of 11 and 4 nM respectively. |
| M2781 | IWP-L6 | IWP-L6 is a highly potent Porcn inhibitor with EC50 of 0.5 nM. |
| M2237 | IWP-2 | IWP-2 is an inhibitor of Wnt production that impairs Wnt pathway activity in vitro with an IC50 value of 27 nM. |
| M2782 | IWR-1-endo | IWR-1 (endo-IWR 1) is a Wnt pathway inhibitor with IC50 of 180 nM, induces Axin2 protein levels and promotes β-catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes. |
| M9790 | BML-284 | BML-284 (Wnt agonist 1) is a potent and selective activator of Wnt signaling. BML-284 induces TCF-dependent transcriptional activity with an EC50 of 700 nM. |
| M14939 | β-catenin-IN-2 | β-catenin-IN-2 is a potent β-catenin inhibitor, compound H1B1, extracted from patent US20150374662A1. β-catenin-IN-2 can be used for the study of colorectal cancer. |
| M14935 | YB-0158 | YB-0158 (Wnt pathway inhibitor 2) is a reverse-turn peptidomimetic and a potent colorectal cancer stem cell (CSC) targeting agent. YB-0158 disrupts Sam68-Src interactions and induces apoptosis in CRC cells. Anti-cancer activities. |
| M14934 | Pyrvinium pamoate | Pyrvinium pamoate is an FDA-approved antihelmintic drug that inhibits WNT pathway signaling. |
| M14933 | KY1220 | KY1220 is a compound that destabilizes both β-catenin and Ras, via targeting the Wnt/β-catenin pathway; with an IC50 of 2.1 μM in HEK293 reporter cells. |
| M14932 | HLY78 | HLY78 is an activator of the Wnt/β-catenin signaling pathway, which targets the DIX domain of Axin and potentiates the Axin-LRP6 association to promote Wnt signaling transduction. |
| M14931 | Gigantol | Gigantol is a bibenzyl compound derived from several medicinal orchids. Giganto shows promising therapeutic potential against cancer cells. Gigantol is a novel inhibitor of the Wnt/β-catenin pathway. |
| M11484 | Cinobufotalin | Cinobufotalin is a cardiotonic steroid, or butadienolide, derived from the skin secretions of toads. SREBP1 is a novel inhibitor that inhibits the proliferation of hepatocellular carcinoma by targeting adipogenesis. |
| M11012 | NLS-StAx-h | NLS-StAx-h is a selective, cell permeable, stapled peptide Wnt signaling inhibitor with an IC50 of 1.4 μM. |
| M10996 | Methyl vanillate | Methyl vanillate, an extract found in the genus Loquat, is a Wnt/β-catenin signaling pathway activator. Benzoate, is the methyl ester of vanillin. It has antioxidant effects. Plant metabolites. |
| M10710 | L-Quebrachitol | L-Quebrachitol is a natural product isolated from a variety of plants that promotes osteoblast production by upregulating BMP-2, runt-associated transcription factor (Runx2), MAPK (ERK, JNK, p38α), and Wnt/β-catenin signaling pathways. |
| M10678 | PRI-724 | PRI-724 (C-82 prodrug, ICG-001 analog) is a potent, specific inhibitor that disrupts the interaction of β-catenin and CBP |
| M10577 | Foxy-5 TFA | As an agonist of WNT5A, FOxy-5 is a formylated WNT5A-mimicking peptide that triggers cytoplasmic free calcium signaling without affecting β-catenin activation and impels epithelial cancer cell migration and invasion. |
| M9544 | Heparan Sulfate | Heparan sulfate is a complex and linear polysaccharide, which expressed abundantly on the cell surface and in the extracellular matrix. |
| M9478 | SKL2001 | SKL2001 is a novel agonist of Wnt/β-catenin pathway with anti-cancer activity. |
| M9424 | Adavivint | Adavivint (SM04690) is a potent and specific inhibitor of canonical Wnt signaling with an EC50 of 19.5 nM for inhibiting the TCF/LEF reporter. |
| M9417 | Gallocyanine | Gallocyanine is a small molecule DKK1 inhibitor, which blocks DKK1 inhibitory activity on Wnt signaling. |
| M8934 | ETC-159 | ETC-159 is a potent, selective and orally available PORCN inhibitor, which inhibits β-catenin reporter activity with an IC50 of 2.9 nM. |
| M8690 | KYA1797K potassium salt | KYA1797K is an inhibitor of both Wnt/β-catenin and Ras pathways. |
| M8637 | MSAB | MSAB is a potent and selective, cell-permeable compound that targets β-catenin. MSAB binds to β-catenin promoting its degradation, and specifically downregulates Wnt/β-catenin target genes. |
| M8259 | iCRT3 | The key mediator of Wnt signaling is the transcriptional co-activator b-catenin. |
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