| Cat.No. | Name | Information |
|---|---|---|
| M2008 | ICG-001 | ICG-001 is a novel small molecule inhibitor of TCF/beta-catenin-mediated transcription. |
| M1796 | XAV939 | XAV939 is a potent, cell-permeable small molecule inhibitor of the Wnt/β-catenin pathway to TNKS1 and TNKS2 with IC50 values of 11 and 4 nM respectively. |
| M2781 | IWP-L6 | IWP-L6 is a highly potent Porcn inhibitor with EC50 of 0.5 nM. |
| M2237 | IWP-2 | IWP-2 is an inhibitor of Wnt production that impairs Wnt pathway activity in vitro with an IC50 value of 27 nM. |
| M2782 | IWR-1-endo | IWR-1 (endo-IWR 1) is a Wnt pathway inhibitor with IC50 of 180 nM, induces Axin2 protein levels and promotes β-catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes. |
| M9790 | BML-284 | BML-284 (Wnt agonist 1) is a potent and selective activator of Wnt signaling. |
| M11012 | NLS-StAx-h | NLS-StAx-h is a selective fixed peptide inhibitor of Wnt signaling,IC50 1.4 μM. |
| M10996 | Methyl vanillate | Methyl vanillate, an extract found in the genus Loquat, is a Wnt/β-catenin signaling pathway activator. Benzoate, is the methyl ester of vanillin. It has antioxidant effects. Plant metabolites. |
| M10710 | L-Quebrachitol | L-Quebrachitol is a natural product isolated from a variety of plants that promotes osteoblast production by upregulating BMP-2, runt-associated transcription factor (Runx2), MAPK (ERK, JNK, p38α), and Wnt/β-catenin signaling pathways. |
| M10678 | PRI-724 | PRI-724 (C-82 prodrug, ICG-001 analog) is a potent, specific inhibitor that disrupts the interaction of β-catenin and CBP |
| M10577 | Foxy-5 TFA | As an agonist of WNT5A, FOxy-5 is a formylated WNT5A-mimicking peptide that triggers cytoplasmic free calcium signaling without affecting β-catenin activation and impels epithelial cancer cell migration and invasion. |
| M10056 | FIDAS-5 | FIDAS-5 is a potent and orally active methionine S-adenosyltransferase 2A (MAT2A) inhibitor with an IC50 of 2.1 μM. |
| M9544 | Heparan Sulfate | Heparan sulfate is a complex and linear polysaccharide, which expressed abundantly on the cell surface and in the extracellular matrix. |
| M9478 | SKL2001 | SKL2001 is a novel agonist of Wnt/β-catenin pathway with anti-cancer activity. |
| M9424 | Adavivint | Adavivint (SM04690) is a potent and specific inhibitor of canonical Wnt signaling with an EC50 of 19.5 nM for inhibiting the TCF/LEF reporter. |
| M9417 | Gallocyanine | Gallocyanine is a small molecule DKK1 inhibitor, which blocks DKK1 inhibitory activity on Wnt signaling. |
| M8934 | ETC-159 | ETC-159 is a potent, selective and orally available PORCN inhibitor, which inhibits β-catenin reporter activity with an IC50 of 2.9 nM. |
| M8690 | KYA1797K potassium salt | KYA1797K is an inhibitor of both Wnt/β-catenin and Ras pathways. |
| M8637 | MSAB | MSAB is a potent and selective, cell-permeable compound that targets β-catenin. MSAB binds to β-catenin promoting its degradation, and specifically downregulates Wnt/β-catenin target genes. |
| M8259 | iCRT3 | The key mediator of Wnt signaling is the transcriptional co-activator b-catenin. |
| M8173 | Salinomycin | Salinomycin is a carboxylic polyether ionophore with antibiotic and anti-cancer properties. |
| M7992 | PNU-74654 | PNU-74654 inhibits the Wnt-β catenin pathway by blocking the interaction between β-catenin and TCF (T cell factor). |
| M7024 | Neurodazine | Neurodazin is a compound that induces neurogenesis in mature skeletal muscle cells. |
| M6855 | JW 74 | JW 74 is a wnt pathway inhibitor, with an IC50 of 420 nM. |
| M6854 | JW 67 | JW 67 is a wnt pathway inhibitor; induces degradation of active β-catenin. |
| M6839 | IWP 4 | IWP 4 is a potent inhibitor of Wnt/β-catenin signaling. |
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