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Wnt/beta-catenin Wnt/beta-catenin

Inhibitors

Cat.No.  Name Information
M2008 ICG-001 ICG-001 is a novel small molecule inhibitor of TCF/beta-catenin-mediated transcription.
M1796 XAV939 XAV939 is a potent, cell-permeable small molecule inhibitor of the Wnt/β-catenin pathway to TNKS1 and TNKS2 with IC50 values of 11 and 4 nM respectively.
M2781 IWP-L6 IWP-L6 is a highly potent Porcn inhibitor with EC50 of 0.5 nM.
M2237 IWP-2 IWP-2 is an inhibitor of Wnt production that impairs Wnt pathway activity in vitro with an IC50 value of 27 nM.
M4197 Triptonide Triptonide (NSC 165677) is a natural product identified from Triptonia wilfordii. Triptonide is a Wnt signaling inhibitor with an IC50 of about 0.3 nM. Triptonide has immunosuppressive, anti-inflammatory, anti-fertility, neuroprotective and anti-lymphoma effects.
M4038 Astragaloside-I Astragaloside I is a natural compound isolated from astragalus. Astragaloside I has osteogenic activity by stimulating osteoblast differentiation through the Wnt/β-catenin signaling pathway.
M4003 Isoquercitrin isoquercitrin is an inhibitor of Wnt/β-catenin and should be further investigated as a potential novel anti-tumoral agent.
M3886 WAY-262611 WAY-262611 is a Wnt pathway agonist acting via inhibition of Dkk1 with no GSK-3β inhibition and the TCF-Luciferase EC50=0.63µM.
M3131 Wnt-C59 Wnt-C59 (C59) is a PORCN inhibitor for Wnt3A-mediated activation of a multimerized TCF-binding site driving luciferase with IC50 of 74 pM.
M2812 LGK-974 LGK-974 (WNT-974) is a potent and specific PORCN inhibitor, and inhibits Wnt signaling with IC50 of 0.4 nM.
M2800 KY02111 KY02111 promotes differentiation of hPSCs to cardiomyocytes by inhibiting Wnt signaling, may act downstream of APC and GSK3β.
M2782 IWR-1-endo IWR-1 (endo-IWR 1) is a Wnt pathway inhibitor with IC50 of 180 nM, induces Axin2 protein levels and promotes β-catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes.
M2781 IWP-L6 IWP-L6 is a highly potent Porcn inhibitor with EC50 of 0.5 nM.
M2237 IWP-2 IWP-2 is an inhibitor of Wnt production that impairs Wnt pathway activity in vitro with an IC50 value of 27 nM.
M2008 ICG-001 ICG-001 is a novel small molecule inhibitor of TCF/beta-catenin-mediated transcription.
M1796 XAV939 XAV939 is a potent, cell-permeable small molecule inhibitor of the Wnt/β-catenin pathway to TNKS1 and TNKS2 with IC50 values of 11 and 4 nM respectively.



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