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Foxy-5 TFA, a WNT5A agonist, is a mimicking peptide of WNT5A which is a non-canonical member of the Wnt family. Foxy-5 TFA triggers cytosolic free calcium signaling without affecting β-catenin activation and it impairs the migration and invasion of epithelial cancer cells.
Foxy-5 effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model. Foxy-5 reduces the number of colonic cancer stem cells in a xenograft mouse model of human colonic cancer.
| Molecular Weight | 808.80 |
| Formula | C28H43F3N6O14S2 |
| CAS Number | 881188-51-8 (free base) |
| Solubility (25°C) | Water 18 mg/mL |
| Storage | -20°C, dry, sealed |
| Related Wnt/beta-catenin Products |
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