Free shipping on all orders over $ 500

L-Quebrachitol

Cat. No. M10710
L-Quebrachitol Structure
Synonym:

L-白雀木醇

Size Price Availability Quantity
10mg USD 80  USD80 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

L-Quebrachitol is a natural product isolated from a variety of plants that promotes osteoblast production by upregulating BMP-2, runt-associated transcription factor (Runx2), MAPK (ERK, JNK, p38α), and Wnt/β-catenin signaling pathways.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 194.18
Formula C7H14O6
CAS Number 642-38-6
Purity >98%
Solubility DMSO ≥ 100 mg/mL
Storage at -20°C
References

[1] Qifan Zhou, et al. J Org Chem. l -( -) -Quebrachitol as a Ligand for Selective Copper(0)-Catalyzed N-Arylation of Nitrogen-Containing Heterocycles

[2] Mara Yolanda Rios, et al. Pest Manag Sci. Phytotoxic and nematicide evaluation of Croton ehrenbergii (Euphorbiaceae)

[3] Thanintorn Yodthong, et al. Molecules. l-Quebrachitol Promotes the Proliferation, Differentiation, and Mineralization of MC3T3-E1 Cells: Involvement of the BMP-2/Runx2/MAPK/Wnt/β-Catenin Signaling Pathway

[4] Martina Daz, et al. Carbohydr Res. First record of L-quebrachitol in Allophylus edulis (Sapindaceae)

[5] L Qiao, et al. Org Lett. A versatile approach to PI(3,4)P2, PI(4,5)P2, and PI(3,4,5)P3 from L-(-)-quebrachitol

Related Wnt/beta-catenin Products
NLS-StAx-h

NLS-StAx-h is a selective fixed peptide inhibitor of Wnt signaling,IC50 1.4 μM.

Methyl vanillate

Methyl vanillate, an extract found in the genus Loquat, is a Wnt/β-catenin signaling pathway activator. Benzoate, is the methyl ester of vanillin. It has antioxidant effects. Plant metabolites.

PRI-724

PRI-724 (C-82 prodrug, ICG-001 analog) is a potent, specific inhibitor that disrupts the interaction of β-catenin and CBP

Foxy-5 TFA

Foxy-5 TFA, a WNT5A agonist, is a mimicking peptide of WNT5A which is a non-canonical member of the Wnt family. Foxy-5 TFA triggers cytosolic free calcium signaling without affecting β-catenin activation and it impairs the migration and invasion of epithelial cancer cells.

FIDAS-5

FIDAS-5 is a potent and orally active methionine S-adenosyltransferase 2A (MAT2A) inhibitor with an IC50 of 2.1 μM.

  Catalog
Abmole Inhibitor Catalog




Keywords: L-Quebrachitol, L-白雀木醇 supplier, Wnt/beta-catenin, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.