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SKL2001

Cat. No. M9478
SKL2001 Structure
Synonym:

Wnt Agonist II

Size Price Availability Quantity
10mg USD 70  USD70 In stock
50mg USD 290  USD290 In stock
100mg USD 520  USD520 In stock
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Quality Control
Biological Activity

SKL2001 is a novel agonist of Wnt/β-catenin pathway with anti-cancer activity. SKL2001 suppresses colon cancer spheroid growth through regulation of the E-cadherin/β-Catenin complex. SKL2001 inhibited proliferation of colon cancer cells cultured in 3D spheroid and induced them accumulation in the G0/G1 phase of the cell cycle with a reduced c-myc level. SKL2001 (5, 10, and 30 μM) stabilizes intracellular β-catenin in 3T3-L1 cells. SKL2001 (40 μM) significantly inhibits the proliferation of HCT116 spheroids independently of cytotoxicity and the inhibition is reversible.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 286.29
Formula C14H14N4O3
CAS Number 909089-13-0
Purity >99%
Solubility DMSO ≥ 60 mg/mL
Storage at -20°C
References

[1] Huang HL, et al. Can J Physiol Pharmacol. Role of Wnt/β-catenin pathway agonist SKL2001 in Caerulein-induced acute pancreatitis.

[2] Ohashi W, et al. Biochem Biophys Res Commun. SKL2001 suppresses colon cancer spheroid growth through regulation of the E-cadherin/β-Catenin complex.

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Keywords: SKL2001, Wnt Agonist II supplier, Wnt/beta-catenin, inhibitors

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