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SKL2001

Cat. No. M9478
SKL2001 Structure
Synonym:

Wnt Agonist II

Size Price Availability Quantity
50mg USD 270  USD300 In stock
100mg USD 468  USD520 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

SKL2001 is a novel agonist of Wnt/β-catenin pathway with anti-cancer activity. SKL2001 suppresses colon cancer spheroid growth through regulation of the E-cadherin/β-Catenin complex. SKL2001 inhibited proliferation of colon cancer cells cultured in 3D spheroid and induced them accumulation in the G0/G1 phase of the cell cycle with a reduced c-myc level. SKL2001 (5, 10, and 30 μM) stabilizes intracellular β-catenin in 3T3-L1 cells. SKL2001 (40 μM) significantly inhibits the proliferation of HCT116 spheroids independently of cytotoxicity and the inhibition is reversible.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 286.29
Formula C14H14N4O3
CAS Number 909089-13-0
Purity >98%
Solubility DMSO ≥ 60 mg/mL
Storage at -20°C
References

Role of Wnt/β-catenin pathway agonist SKL2001 in Caerulein-induced acute pancreatitis.
Huang HL, et al. Can J Physiol Pharmacol. 2019 Jan;97(1):15-22. PMID: 30326193.

SKL2001 suppresses colon cancer spheroid growth through regulation of the E-cadherin/β-Catenin complex.
Ohashi W, et al. Biochem Biophys Res Commun. 2017 Nov 25;493(3):1342-1348. PMID: 28970068.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: SKL2001, Wnt Agonist II supplier, Wnt/beta-catenin, inhibitors

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