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Heparan Sulfate

Cat. No. M9544
Heparan Sulfate Structure
Size Price Availability Quantity
5mg USD 440  USD440 In stock
10mg USD 800  USD800 In stock
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Quality Control & Documentation
  • Purity: Potency ≥60IU/MG, BR
  • COA
  • MSDS
Biological Activity

Heparan sulfate is a complex and linear polysaccharide, which expressed abundantly on the cell surface and in the extracellular matrix.

Chemical Information
Molecular Weight 593.47
Formula C12H19NO20S3 (monomer)
CAS Number 9050-30-0
Solubility (25°C) Water ≥ 35 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Yona Nadir. Effect of Heparanase and Heparan Sulfate Chains in Hemostasis

[2] Alejandro Gmez Toledo, et al. A Systems View of the Heparan Sulfate Interactome

[3] Mohit Chhabra, et al. PI-88 and Related Heparan Sulfate Mimetics

[4] Barbara Bartolini, et al. Heparan Sulfate in the Tumor Microenvironment

[5] J-P Li, et al. Heparan Sulfate: Biosynthesis, Structure, and Function

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