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KY1220

Cat. No. M14933

All AbMole products are for research use only, cannot be used for human consumption.

KY1220 Structure
Size Price Availability Quantity
1mg USD 35  USD35 In stock
5mg USD 80  USD80 In stock
10mg USD 140  USD140 In stock
25mg USD 280  USD280 In stock
50mg USD 440  USD440 In stock
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Quality Control & Documentation
Biological Activity

KY1220 is a compound that destabilizes both β-catenin and Ras, via targeting the Wnt/β-catenin pathway; with an IC50 of 2.1 μM in HEK293 reporter cells.

Chemical Information
Molecular Weight 314.32
CAS Number 292168-79-7
Solubility (25°C) DMSO ≥ 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Yong-Hee Cho, et al. KY1022, a small molecule destabilizing Ras via targeting the Wnt/β-catenin pathway, inhibits development of metastatic colorectal cancer

[2] Pu-Hyeon Cha, et al. Simultaneous destabilization of β-catenin and Ras via targeting of the axin-RGS domain as a potential therapeutic strategy for colorectal cancer

[3] Pu-Hyeon Cha, et al. Small-molecule binding of the axin RGS domain promotes β-catenin and Ras degradation

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Keywords: KY1220 supplier, Wnt/beta-catenin, inhibitors, activators

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